PXD008036

PXD008036 is an original dataset announced via ProteomeXchange.

Title	Olfactory proteomics in Parkinson disease
Description	Olfactory dysfunction is one of the earliest features in Lewy-type alpha-synucleinopathies (LTS) such as Parkinson´s disease (PD). However, the underlying molecular mechanisms associated to smell impairment is poorly understood. To reveal the missing links in the biochemical understanding of olfactory dysfunction in PD, we have applied mass spectrometry-based proteomics in postmortem olfactory bulbs (OBs) dissected from parkinsonian subjects with different LTS staging respect to elderly controls (n= 24, mean age 79 years).
HostingRepository	PRIDE
AnnounceDate	2018-10-24
AnnouncementXML	Submission_2018-10-24_07:01:41.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Enrique Santamaría
SpeciesList	scientific name: Homo sapiens (Human); NCBI TaxID: 9606;
ModificationList	monohydroxylated residue; acetylated residue; iodoacetamide derivatized residue
Instrument	TripleTOF 5600

Revision	Datetime	Status	ChangeLog Entry
0	2017-10-24 08:41:22	ID requested
⏵ 1	2018-10-24 07:01:43	announced

Lach, é, n-Montes M, Gonz, á, lez-Morales A, Iloro I, Elortza F, Ferrer I, Gveric D, Fern, á, ndez-Irigoyen J, Santamar, í, a E, Unveiling the olfactory proteostatic disarrangement in Parkinson's disease by proteome-wide profiling. Neurobiol Aging, 73():123-134(2019) [pubmed]

curator keyword: Biological, Biomedical

submitter keyword: proteomics, olfactory bulb, Parkinson

Enrique Santamaria
contact affiliation	Clinical Neuroproteomics Lab Navarrabiomed Proteored Pamplona, Spain
contact email	esantamma@navarra.es
lab head
Enrique Santamaría
contact affiliation	Proteomics unit
contact email	esantamma@navarra.es
dataset submitter

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2018/10/PXD008036

PRIDE project URI

• PRIDE
  1. PXD008036
     1. Label: PRIDE project
     2. Name: Olfactory proteomics in Parkinson disease