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PXD008019

DataSet Summary

  • HostingRepository: PRIDE
  • AnnounceDate: 2018-07-11
  • AnnouncementXML: Submission_2018-07-11_09:29:25.xml
  • DigitalObjectIdentifier:
  • ReviewLevel: Peer-reviewed dataset
  • DatasetOrigin: Original data
  • RepositorySupport: Unsupported dataset by repository
  • PrimarySubmitter: Hanna Sidjabat
  • Title: First dataset - bacterial proteome of carbapanemase-producing Escherichia coli and other Enterobacteriaceae under antibiotic pressure
  • Description: Antibiotic resistance associated with the expression of the clinically significant carbapenemases, IMP, KPC, and NDM and OXA-48 in Enterobacteriaceae is emerging as a worldwide calamity to health care. In Australia, IMP-producing Enterobacteriaceae is the most prevalent carbapenemase-producing Enterobacteriaceae (CPE). Genomic characteristics of such carbapenemase-producing Enterobacteriaceae (CPE) are well described, but the corresponding proteome is poorly characterised. We have thus developed a method to analyse dynamic changes in the proteome of CPE under antibiotic pressure. Specifically, we have investigated the effect of meropenem at sub-lethal concentrations to develop a better understanding of how antibiotic pressure leads to resistance. Escherichia coli, producing either NDM, IMP or KPC type carbapenemase were included in this study, and their proteomes were analysed in growth conditions with or without meropenem.
  • SpeciesList: scientific name: Escherichia coli; NCBI TaxID: 562;
  • ModificationList: No PTMs are included in the dataset
  • Instrument: TripleTOF 5600

Dataset History

VersionDatetimeStatusChangeLog Entry
02017-10-23 02:35:04ID requested
12018-07-11 09:29:26announced

Publication List

  1. Sidjabat HE, Gien J, Kvaskoff D, Ashman K, Vaswani K, Reed S, McGeary RP, Paterson DL, Bordin A, Schenk G, The use of SWATH to analyse the dynamic changes of bacterial proteome of carbapanemase-producing Escherichia coli under antibiotic pressure. Sci Rep, 8(1):3871(2018) [pubmed]

Keyword List

  1. curator keyword: Biomedical
  2. submitter keyword: Antibiotic resistance, proteomics, SWATH analysis, carbapenemases, IMP, NDM, KPC

Contact List

    Hanna Sidjabat
    • contact affiliation: The University of Queensland, Centre for Clinical Research, Faculty of Medicine.
    • contact email: h.sidjabat@uq.edu.au
    • lab head:
    Hanna Sidjabat
    • contact affiliation: The University of Queensland
    • contact email: h.sidjabat@uq.edu.au
    • dataset submitter:

Full Dataset Link List

  1. Dataset FTP location
  2. PRIDE project URI
Repository Record List
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