PXD007985

PXD007985 is an original dataset announced via ProteomeXchange.

Title	Deep Multilayer Tissue Proteomics Identifies Molecular Networks in Alzheimer???s Disease Progression, human data
Description	The molecular networks underlying Alzheimer???s disease (AD) are not well-defined. We present temporal profiling of >14,000 proteins and >34,000 phosphosites at the asymptomatic and symptomatic stages of AD, deep proteomics analysis of transgenic mouse models.
HostingRepository	PRIDE
AnnounceDate	2019-11-26
AnnouncementXML	Submission_2020-09-28_01:26:47.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	xusheng wang
SpeciesList	scientific name: Homo sapiens (Human); NCBI TaxID: 9606;
ModificationList	phosphorylated residue; monohydroxylated residue
Instrument	Q Exactive; LTQ Orbitrap Elite

Revision	Datetime	Status	ChangeLog Entry
0	2017-10-17 08:21:56	ID requested
1	2019-11-11 01:59:03	announced
2	2019-11-26 05:37:14	announced	2019-11-26: Updated project metadata.
⏵ 3	2020-09-28 01:26:48	announced	2019-11-26: Updated project metadata. 2020-09-28: Updated publication reference for PubMed record(s): 31926610.

Bai B, Wang X, Li Y, Chen PC, Yu K, Dey KK, Yarbro JM, Han X, Lutz BM, Rao S, Jiao Y, Sifford JM, Han J, Wang M, Tan H, Shaw TI, Cho JH, Zhou S, Wang H, Niu M, Mancieri A, Messler KA, Sun X, Wu Z, Pagala V, High AA, Bi W, Zhang H, Chi H, Haroutunian V, Zhang B, Beach TG, Yu G, Peng J, Deep Multilayer Brain Proteomics Identifies Molecular Networks in Alzheimer's Disease Progression. Neuron, 105(6):975-991.e7(2020) [pubmed]

curator keyword: Biomedical

submitter keyword: Alzheimer???s disease

mass spectrometry

proteomics

proteome

phosphoproteome

transcriptome

RNA-seq

genomics

genome

systems biology

disease network

A??

Tau

netrin

Junmin Peng
contact affiliation	St. Jude Children's Research Hospital
contact email	junmin.peng@stjude.org
lab head
xusheng wang
contact affiliation	Proteomics
contact email	xushengwang78@gmail.com
dataset submitter

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2019/11/PXD007985

PRIDE project URI

• PRIDE
  1. PXD007985
     1. Label: PRIDE project
     2. Name: Deep Multilayer Tissue Proteomics Identifies Molecular Networks in Alzheimer???s Disease Progression, human data