PXD007982

PXD007982 is an original dataset announced via ProteomeXchange.

Title	Quantitive protein profiling and pathway analysis for spinal arteriovenous malformations
Description	Spinal arteriovenous malformations (sAVM) were rare and heterogeneous group of blood vessel disorders that affected the function of spinal cord directly or indirectly. In the past decades, the pathogenesis for SAVM was still not elucidated. Here we compared the specimens of four sAVM obtained from surgery and control samples from donations using TMT labeled proteomic study. In our proteomic study, we identified a total of 3101 proteins and 654-proteins were changed in SAVM compares with control, among which 96 proteins were upregulated and 358 proteins were downregulated. Gene Ontology (GO) analysis revealed that extracellular matrix organization in biological process and integrin binding proteins in molecular function were the most enriched items. Four significant changed proteins (PLG, MPZ, MMP9 and RPL23a) were verified by Western blot. The pathway analysis revealed that the changed proteins in pathways of angiogenesis, focal adhesion and cytoplasmic ribosome likely contributed to SAVM. The protein profile changes identified by our proteomic studies provide a comprehensive understanding of sAVM for us.
HostingRepository	PRIDE
AnnounceDate	2018-06-18
AnnouncementXML	Submission_2018-06-18_01:51:48.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Wei Ge
SpeciesList	scientific name: Homo sapiens (Human); NCBI TaxID: 9606;
ModificationList	TMT6plex-126 reporter+balance reagent acylated residue; iodoacetamide derivatized residue
Instrument	Q Exactive

Revision	Datetime	Status	ChangeLog Entry
0	2017-10-17 07:26:27	ID requested
⏵ 1	2018-06-18 01:51:49	announced

Guo Y, Xu B, Sun Z, Wu Y, Shi W, Wang J, Meng X, Ge W, Wang G, Quantitative protein profiling and pathway analysis of spinal arteriovenous malformations. Microvasc Res, 120():47-54(2018) [pubmed]

curator keyword: Biomedical

submitter keyword: Spinal arteriovenous malformation, Proteomic, Angiogenesis, Focal adhesion, Ribosome

Wei Ge
contact affiliation	State Key Laboratory of Medical Molecular Biology & Department of Immunology, Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences, No. 5 Dongdansantiao, Dongcheng District, Beijing, 100005 China
contact email	wei.ge@chem.ox.ac.uk
lab head
Wei Ge
contact affiliation	National Key Laboratory of Medical Molecular Biology & Department of Immunology, Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences
contact email	wei.ge@chem.ox.ac.uk
dataset submitter

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PRIDE project URI

• PRIDE
  1. PXD007982
     1. Label: PRIDE project
     2. Name: Quantitive protein profiling and pathway analysis for spinal arteriovenous malformations