PXD007920

PXD007920 is an original dataset announced via ProteomeXchange.

Dataset Summary

Title	Differential kinobeads selectivity profiling
Description	The goal of this project was to use differential kinobeads profiling for the discrimination of reversible and irreversible kinase targets of different covalent kinase inhibitors. For this, differences in target engagement measured in a lysate- and a cell-based kinobeads assay were compared in a kinome-wide scale.
HostingRepository	PRIDE
AnnounceDate	2017-10-13
AnnouncementXML	Submission_2017-10-13_05:37:59.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Maria Faelth Savitski
SpeciesList	scientific name: Homo sapiens (Human); NCBI TaxID: 9606;
ModificationList	TMT6plex-126 reporter+balance reagent acylated residue; monohydroxylated residue; acetylated residue; iodoacetamide derivatized residue
Instrument	Orbitrap Fusion Lumos; Q Exactive

Dataset History

Revision	Datetime	Status	ChangeLog Entry
0	2017-10-09 02:36:47	ID requested
⏵ 1	2017-10-13 05:38:00	announced

Publication List

Dittus L, Werner T, Muelbaier M, Bantscheff M, Differential Kinobeads Profiling for Target Identification of Irreversible Kinase Inhibitors. ACS Chem Biol, 12(10):2515-2521(2017) [pubmed]

Dittus L, Werner T, Muelbaier M, Bantscheff M, Differential Kinobeads Profiling for Target Identification of Irreversible Kinase Inhibitors. ACS Chem Biol, 12(10):2515-2521(2017) [pubmed]

Keyword List

curator keyword: Technical
submitter keyword: Acalabrutinib, CC-292, Ibrutinib, 5Z-7-Oxozeaenol, saturated Ibrutinib, A549 lung epithelia cell line, Ramos B-lymphocyte, cell-based assay, lysate-based assay, kinobeads, LC-MS/MS

curator keyword: Technical

submitter keyword: Acalabrutinib, CC-292, Ibrutinib, 5Z-7-Oxozeaenol, saturated Ibrutinib, A549 lung epithelia cell line, Ramos B-lymphocyte, cell-based assay, lysate-based assay, kinobeads, LC-MS/MS

Contact List

Marcus Bantscheff
contact affiliation	Cellzome
contact email	marcus.x.bantscheff@gsk.com
lab head
Maria Faelth Savitski
contact affiliation	Cellzome
contact email	maria.x.faelth-savitski@gsk.com
dataset submitter

Full Dataset Link List

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2017/10/PXD007920
PRIDE project URI

Dataset FTP location
NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2017/10/PXD007920

PRIDE project URI

Repository Record List

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