PXD007906

PXD007906 is an original dataset announced via ProteomeXchange.

Title	A secretome profile indicative of oleate-induced proliferation of HepG2 hepatocellular carcinoma cell line
Description	Increased fatty acid (FA) is often observed in highly proliferative tumors, contributing to promoting proliferation of tumor cells. FA affects secreted factors from tumor cells, which can modulate tumor microenvironment in favor of tumor survival. However, the secreted factors affected by the increased FA have not been systematically explored. Here, we performed comprehensive secretome profiling of oleate-treated and untreated HepG2 cells. Comparison of the secretomes identified 349 differentially secreted proteins (DSPs; 145 up-regulated and 192 down-regulated) in oleate-treated samples, compared to untreated samples. Functional enrichment and network analyses of the DSPs revealed that the 145 up-regulated secreted proteins by oleate treatment were mainly associated with cell proliferation-related processes, such as lipid metabolism, inflammatory response, and ER stress. Based on the network models of the DSPs, we selected four up-regulated secreted proteins (MIF, THBS1, PDIA3, and APOA1) that can represent such processes related to cell proliferation. Thus, our results provided a secretome profile indicative of oleate-induced proliferation of HepG2 cells.
HostingRepository	PRIDE
AnnounceDate	2024-10-22
AnnouncementXML	Submission_2024-10-22_04:14:28.879.xml
DigitalObjectIdentifier	https://dx.doi.org/10.6019/PXD007906
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Supported dataset by repository
PrimarySubmitter	Ji-Hwan Park
SpeciesList	scientific name: Homo sapiens (Human); NCBI TaxID: 9606;
ModificationList	Oxidation; Carbamidomethyl
Instrument	Q Exactive

Revision	Datetime	Status	ChangeLog Entry
0	2017-10-04 09:09:45	ID requested
1	2018-08-08 10:05:44	announced
⏵ 2	2024-10-22 04:14:35	announced	2024-10-22: Updated project metadata.

Park S, Park JH, Jung HJ, Jang JH, Ahn S, Kim Y, Suh PG, Chae S, Yoon JH, Ryu SH, Hwang D, A secretome profile indicative of oleate-induced proliferation of HepG2 hepatocellular carcinoma cells. Exp Mol Med, 50(8):1-14(2018) [pubmed]

10.6019/PXD007906;

10.1038/s12276-018-0120-3;

curator keyword: Biological

submitter keyword: Human, hepatocellular carcinoma, Oleate, HepG2

Daehee Hwang
contact affiliation	Center for Plant Aging Research, Institute for Basic Science, Daegu Gyeongbuk Institute of Science and Technology (DGIST), Daegu, Republic of Korea
contact email	dhwang@dgist.ac.kr
lab head
Ji-Hwan Park
contact affiliation	Korea Bioinformation Center (KOBIC), Korea Research Institute of Bioscience and Biotechnology (KRIBB)
contact email	kp706@postech.ac.kr
dataset submitter

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PRIDE project URI

• PRIDE
  1. PXD007906
     1. Label: PRIDE project
     2. Name: A secretome profile indicative of oleate-induced proliferation of HepG2 hepatocellular carcinoma cell line