PXD007871 is an
original dataset announced via ProteomeXchange.
Dataset Summary
Title | Proteomic analysis of human PARK2 knockout iPSC-derived neurons |
Description | Mitochondrial dysfunction plays a major role in the pathogenesis of sporadic Parkinson’s disease (PD) and familial PD caused by mutations in the PARK2 gene. The protein, parkin, is vital for mitochondrial function, but the lack of key PD phenotypes in PARK2 knockout (KO) rodent models has hindered investigations into parkin’s role in PD pathogenesis. Human isogenic induced pluripotent stem cell (iPSC) lines with and without PARK2 KO enable studies of the effect of parkin dysfunction in dopaminergic neuronal cultures. |
HostingRepository | PRIDE |
AnnounceDate | 2019-09-03 |
AnnouncementXML | Submission_2019-09-03_02:01:35.xml |
DigitalObjectIdentifier | |
ReviewLevel | Peer-reviewed dataset |
DatasetOrigin | Original dataset |
RepositorySupport | Unsupported dataset by repository |
PrimarySubmitter | Pia Jensen |
SpeciesList | scientific name: Homo sapiens (Human); NCBI TaxID: 9606; |
ModificationList | TMT6plex-126 reporter+balance reagent acylated residue; N-ethylmaleimide derivatized cysteine; phosphorylated residue |
Instrument | Q Exactive |
Dataset History
Revision | Datetime | Status | ChangeLog Entry |
0 | 2017-09-29 05:36:05 | ID requested | |
⏵ 1 | 2019-09-03 02:01:37 | announced | |
Publication List
Bogetofte H, Jensen P, Okarmus J, Schmidt SI, Agger M, Ryding M, N, ø, rregaard P, Fenger C, Zeng X, Graakj, æ, r J, Ryan BJ, Wade-Martins R, Larsen MR, Meyer M, Perturbations in RhoA signalling cause altered migration and impaired neuritogenesis in human iPSC-derived neural cells with PARK2 mutation. Neurobiol Dis, 132():104581(2019) [pubmed] |
Keyword List
curator keyword: Biological |
submitter keyword: Human iPS cells, LC-MSMS, QExactive-HF, Parkinson's disease |
Contact List
Martin Røssel Larsen |
contact affiliation | Department of Biochemistry and Molecular Biology, Protein Research group, University of Southern Denmark, Odense, Denmark |
contact email | mrl@bmb.sdu.dk |
lab head | |
Pia Jensen |
contact affiliation | University of Southern Denmark |
contact email | pjensen@bmb.sdu.dk |
dataset submitter | |
Full Dataset Link List
Dataset FTP location
NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2019/09/PXD007871 |
PRIDE project URI |
Repository Record List
[ + ]
[ - ]
- PRIDE
- PXD007871
- Label: PRIDE project
- Name: Proteomic analysis of human PARK2 knockout iPSC-derived neurons