PXD007813

PXD007813 is an original dataset announced via ProteomeXchange.

Title	Time-dependent olfactory proteomics in Tg2576 mice
Description	Olfaction is often deregulated in Alzheimer´s disease (AD) patients, being also impaired in transgenic Tg2576 AD mouse model, which overexpress the Swedish mutated form of human amyloid precursor protein (APP). However, little is known about the molecular mechanisms that accompany the neurodegeneration of olfactory structures in Tg2576 mice. For that, we have applied proteome-wide approaches to probe molecular disturbances in the olfactory bulb (OB) dissected from Tg2576 mice respect to age matched wild-type littermates (2 and 6 months of age).
HostingRepository	PRIDE
AnnounceDate	2019-06-28
AnnouncementXML	Submission_2019-06-28_05:14:33.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Enrique Santamaría
SpeciesList	scientific name: Mus musculus (Mouse); NCBI TaxID: 10090;
ModificationList	methylthiolated residue; iTRAQ8plex-116 reporter+balance reagent acylated residue; monohydroxylated residue
Instrument	TripleTOF 5600

Revision	Datetime	Status	ChangeLog Entry
0	2017-09-21 01:10:59	ID requested
⏵ 1	2019-06-28 05:14:34	announced

Lachen-Montes M, Gonz, á, lez-Morales A, Palomino M, Ausin K, G, ó, mez-Ochoa M, Zelaya MV, Ferrer I, P, é, rez-Mediavilla A, Fern, á, ndez-Irigoyen J, Santamar, í, a E, Early-Onset Molecular Derangements in the Olfactory Bulb of Tg2576 Mice: Novel Insights Into the Stress-Responsive Olfactory Kinase Dynamics in Alzheimer's Disease. Front Aging Neurosci, 11():141(2019) [pubmed]

curator keyword: Biological, Biomedical

submitter keyword: olfactory bulb, proteomics, Alzheimer

Enrique Santamaria
contact affiliation	Proteomics Unit, Navarrabiomed-Proteored (Pamplona-Spain)
contact email	esantamma@navarra.es
lab head
Enrique Santamaría
contact affiliation	Proteomics unit
contact email	esantamma@navarra.es
dataset submitter

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2019/06/PXD007813

PRIDE project URI

• PRIDE
  1. PXD007813
     1. Label: PRIDE project
     2. Name: Time-dependent olfactory proteomics in Tg2576 mice