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PXD007809

PXD007809 is an original dataset announced via ProteomeXchange.

Dataset Summary
TitleInfluenza A virus induces autophagosomal targeting of ribosomal proteins
DescriptionSeasonal epidemics of influenza A virus are a major cause of severe illness and are of high socio-economic relevance. For the design of effective anti-viral therapies, a detailed knowledge of cellular pathways perturbed by virus infection is critical. We performed comprehensive expression and organellar proteomics experiments to identify new protein targets and cellular pathways affected by influenza A virus. Type I as well as type II interferon pathways were upregulated upon infection, affecting amongst others poly ADP-ribose polymerase transcription factors and ubiquitin-like modifiers. In addition, influenza A virus had a major influence on the subcellular localization of proteins and complexes. The vesicular compartment appeared expanded upon infection and in particular the composition of autophagsomes was altered, virus infection leading to targeting of ribosomes to autophagosomes.
HostingRepositoryPRIDE
AnnounceDate2024-10-22
AnnouncementXMLSubmission_2024-10-22_04:40:52.900.xml
DigitalObjectIdentifier
ReviewLevelPeer-reviewed dataset
DatasetOriginOriginal dataset
RepositorySupportUnsupported dataset by repository
PrimarySubmitterJoern Dengjel
SpeciesList scientific name: Homo sapiens (Human); NCBI TaxID: 9606;
ModificationListNo PTMs are included in the dataset
InstrumentLTQ Orbitrap
Dataset History
RevisionDatetimeStatusChangeLog Entry
02017-09-20 23:59:24ID requested
12018-07-12 08:57:07announced
22024-10-22 04:41:01announced2024-10-22: Updated project metadata.
Publication List
Becker AC, Gannag, é M, Giese S, Hu Z, Abou-Eid S, Roubaty C, Paul P, B, ü, hler L, Gretzmeier C, Dumit VI, Kaeser-Pebernard S, Schwemmle M, M, ü, nz C, Dengjel J, Influenza A Virus Induces Autophagosomal Targeting of Ribosomal Proteins. Mol Cell Proteomics, 17(10):1909-1921(2018) [pubmed]
10.1074/mcp.ra117.000364;
Keyword List
curator keyword: Biomedical
submitter keyword: Human, Influenza, Ribosome, Autophagosome, Autophagy, Organelle, LC-MS/MS
Contact List
Joern Dengjel
contact affiliationDr. Jörn Dengjel Department of Biology, University of Fribourg Chemin du Musée 10, 1700 Fribourg, Switzerland T +41 26 300 8631 E joern.dengjel@unifr.ch F +41 26 300 9741
contact emailjoern.dengjel@unifr.ch
lab head
Joern Dengjel
contact affiliationUniversity of Fribourg
contact emailjoern.dengjel@medizin.uni-freiburg.de
dataset submitter
Full Dataset Link List
Dataset FTP location
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PRIDE project URI
Repository Record List
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