PXD007809

PXD007809 is an original dataset announced via ProteomeXchange.

Title	Influenza A virus induces autophagosomal targeting of ribosomal proteins
Description	Seasonal epidemics of influenza A virus are a major cause of severe illness and are of high socio-economic relevance. For the design of effective anti-viral therapies, a detailed knowledge of cellular pathways perturbed by virus infection is critical. We performed comprehensive expression and organellar proteomics experiments to identify new protein targets and cellular pathways affected by influenza A virus. Type I as well as type II interferon pathways were upregulated upon infection, affecting amongst others poly ADP-ribose polymerase transcription factors and ubiquitin-like modifiers. In addition, influenza A virus had a major influence on the subcellular localization of proteins and complexes. The vesicular compartment appeared expanded upon infection and in particular the composition of autophagsomes was altered, virus infection leading to targeting of ribosomes to autophagosomes.
HostingRepository	PRIDE
AnnounceDate	2024-10-22
AnnouncementXML	Submission_2024-10-22_04:40:52.900.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Joern Dengjel
SpeciesList	scientific name: Homo sapiens (Human); NCBI TaxID: 9606;
ModificationList	No PTMs are included in the dataset
Instrument	LTQ Orbitrap

Revision	Datetime	Status	ChangeLog Entry
0	2017-09-20 23:59:24	ID requested
1	2018-07-12 08:57:07	announced
⏵ 2	2024-10-22 04:41:01	announced	2024-10-22: Updated project metadata.

Becker AC, Gannag, é M, Giese S, Hu Z, Abou-Eid S, Roubaty C, Paul P, B, ü, hler L, Gretzmeier C, Dumit VI, Kaeser-Pebernard S, Schwemmle M, M, ü, nz C, Dengjel J, Influenza A Virus Induces Autophagosomal Targeting of Ribosomal Proteins. Mol Cell Proteomics, 17(10):1909-1921(2018) [pubmed]

10.1074/mcp.ra117.000364;

curator keyword: Biomedical

submitter keyword: Human, Influenza, Ribosome, Autophagosome, Autophagy, Organelle, LC-MS/MS

Joern Dengjel
contact affiliation	Dr. Jörn Dengjel Department of Biology, University of Fribourg Chemin du Musée 10, 1700 Fribourg, Switzerland T +41 26 300 8631 E joern.dengjel@unifr.ch F +41 26 300 9741
contact email	joern.dengjel@unifr.ch
lab head
Joern Dengjel
contact affiliation	University of Fribourg
contact email	joern.dengjel@medizin.uni-freiburg.de
dataset submitter

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2018/07/PXD007809

PRIDE project URI

• PRIDE
  1. PXD007809
     1. Label: PRIDE project
     2. Name: Influenza A virus induces autophagosomal targeting of ribosomal proteins