PXD007782 is an
original dataset announced via ProteomeXchange.
Dataset Summary
Title | The surface proteome of extracellular vesicles from Fasciola hepatica |
Description | Helminth parasites secrete extracellular vesicles (EVs) as a means of exporting effector molecules into the host microenvironment. Once released, the parasite-derived EVs are internalised by host immune cells and trigger a range of biological effects including modulation of host immunity. While the molecular cargo of EVs have been characterised in many parasites, little is known about the surface-exposed molecules that may effect ligand-receptor interactions with the target host cell surface that initiate vesicle docking and subsequent internalisation. Here we used a membrane-impermeable biotin reagent to capture proteins displayed on the outer membrane surface of adult F. hepatica EVs and mass spectrometry to identified the surface proteins. |
HostingRepository | PRIDE |
AnnounceDate | 2024-10-07 |
AnnouncementXML | Submission_2024-10-07_10:18:21.957.xml |
DigitalObjectIdentifier | https://dx.doi.org/10.6019/PXD007782 |
ReviewLevel | Peer-reviewed dataset |
DatasetOrigin | Original dataset |
RepositorySupport | Supported dataset by repository |
PrimarySubmitter | Mark Robinson |
SpeciesList | scientific name: Fasciola hepatica (Liver fluke); NCBI TaxID: 6192; |
ModificationList | Deamidated; Oxidation; Dioxidation; Carbamidomethyl; Gln->pyro-Glu |
Instrument | TripleTOF 5600 |
Dataset History
Revision | Datetime | Status | ChangeLog Entry |
0 | 2017-09-18 07:32:25 | ID requested | |
⏵ 1 | 2024-10-07 10:18:22 | announced | |
Publication List
10.6019/PXD007782; |
10.1371/journal.pntd.0007087; |
de la Torre-Escudero E, Gerlach JQ, Bennett APS, Cwiklinski K, Jewhurst HL, Huson KM, Joshi L, Kilcoyne M, O'Neill S, Dalton JP, Robinson MW, Surface molecules of extracellular vesicles secreted by the helminth pathogen Fasciola hepatica direct their internalisation by host cells. PLoS Negl Trop Dis, 13(1):e0007087(2019) [pubmed] |
Keyword List
submitter keyword: Fasciola hepatica, exosome, extracellular vesicle |
Contact List
Mark Robinson |
contact affiliation | School of Biological Sciences Medical Biology Centre Queen's University Belfast Belfast, N. Ireland |
contact email | mark.robinson@qub.ac.uk |
lab head | |
Mark Robinson |
contact affiliation | Queens University Belfast |
contact email | mark.robinson@qub.ac.uk |
dataset submitter | |
Full Dataset Link List
Dataset FTP location
NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2019/11/PXD007782 |
PRIDE project URI |
Repository Record List
[ + ]
[ - ]
- PRIDE
- PXD007782
- Label: PRIDE project
- Name: The surface proteome of extracellular vesicles from Fasciola hepatica