PXD007782

PXD007782 is an original dataset announced via ProteomeXchange.

Dataset Summary

Title	The surface proteome of extracellular vesicles from Fasciola hepatica
Description	Helminth parasites secrete extracellular vesicles (EVs) as a means of exporting effector molecules into the host microenvironment. Once released, the parasite-derived EVs are internalised by host immune cells and trigger a range of biological effects including modulation of host immunity. While the molecular cargo of EVs have been characterised in many parasites, little is known about the surface-exposed molecules that may effect ligand-receptor interactions with the target host cell surface that initiate vesicle docking and subsequent internalisation. Here we used a membrane-impermeable biotin reagent to capture proteins displayed on the outer membrane surface of adult F. hepatica EVs and mass spectrometry to identified the surface proteins.
HostingRepository	PRIDE
AnnounceDate	2024-10-07
AnnouncementXML	Submission_2024-10-07_10:18:21.957.xml
DigitalObjectIdentifier	https://dx.doi.org/10.6019/PXD007782
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Supported dataset by repository
PrimarySubmitter	Mark Robinson
SpeciesList	scientific name: Fasciola hepatica (Liver fluke); NCBI TaxID: 6192;
ModificationList	Deamidated; Oxidation; Dioxidation; Carbamidomethyl; Gln->pyro-Glu
Instrument	TripleTOF 5600

Dataset History

Revision	Datetime	Status	ChangeLog Entry
0	2017-09-18 07:32:25	ID requested
⏵ 1	2024-10-07 10:18:22	announced

Publication List

10.6019/PXD007782;
10.1371/journal.pntd.0007087;
de la Torre-Escudero E, Gerlach JQ, Bennett APS, Cwiklinski K, Jewhurst HL, Huson KM, Joshi L, Kilcoyne M, O'Neill S, Dalton JP, Robinson MW, Surface molecules of extracellular vesicles secreted by the helminth pathogen Fasciola hepatica direct their internalisation by host cells. PLoS Negl Trop Dis, 13(1):e0007087(2019) [pubmed]

10.6019/PXD007782;

10.1371/journal.pntd.0007087;

de la Torre-Escudero E, Gerlach JQ, Bennett APS, Cwiklinski K, Jewhurst HL, Huson KM, Joshi L, Kilcoyne M, O'Neill S, Dalton JP, Robinson MW, Surface molecules of extracellular vesicles secreted by the helminth pathogen Fasciola hepatica direct their internalisation by host cells. PLoS Negl Trop Dis, 13(1):e0007087(2019) [pubmed]

Keyword List

submitter keyword: Fasciola hepatica, exosome, extracellular vesicle

submitter keyword: Fasciola hepatica, exosome, extracellular vesicle

Contact List

Mark Robinson
contact affiliation	School of Biological Sciences Medical Biology Centre Queen's University Belfast Belfast, N. Ireland
contact email	mark.robinson@qub.ac.uk
lab head
Mark Robinson
contact affiliation	Queens University Belfast
contact email	mark.robinson@qub.ac.uk
dataset submitter

Full Dataset Link List

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2019/11/PXD007782
PRIDE project URI

Dataset FTP location
NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2019/11/PXD007782

PRIDE project URI

Repository Record List

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