PXD007781 is an
original dataset announced via ProteomeXchange.
Dataset Summary
Title | Massively parallel genetic resistance screens |
Description | Here we describe the use of multiple forward genetic screens executed in parallel to identify those genes, and their cognate pathways, that when overexpressed, silenced or mutated confer resistance in BRAF mutant colon cancer to a BRAF/MEK/EGFR inhibitor combination. We demonstrate that this resistance landscape is finite, relatively constrained to a small number of pathways and that it is possible to exploit the evolutionary dynamics that underpins the clonal expansion of drug resistant cells therapeutically. |
HostingRepository | PRIDE |
AnnounceDate | 2022-05-30 |
AnnouncementXML | Submission_2022-05-30_08:01:41.096.xml |
DigitalObjectIdentifier | |
ReviewLevel | Peer-reviewed dataset |
DatasetOrigin | Original dataset |
RepositorySupport | Unsupported dataset by repository |
PrimarySubmitter | James Wright |
SpeciesList | scientific name: Homo sapiens (Human); NCBI TaxID: 9606; |
ModificationList | TMT6plex-126 reporter+balance reagent acylated residue; phosphorylated residue; monohydroxylated residue; iodoacetamide derivatized residue; deamidated residue |
Instrument | Orbitrap Fusion |
Dataset History
Revision | Datetime | Status | ChangeLog Entry |
0 | 2017-09-18 07:22:40 | ID requested | |
⏵ 1 | 2022-05-30 08:01:41 | announced | |
Publication List
Dataset with its publication pending |
Keyword List
curator keyword: Biomedical |
submitter keyword: TMT, Cancer, Colon, Phosphoproteomics |
Contact List
Jyoti Choudhary |
contact affiliation | Wellcome Trust Sanger Institute |
contact email | jc4@sanger.ac.uk |
lab head | |
James Wright |
contact affiliation | Proteomic Mass Spectrometry, Wellcome Trust Sanger Institute |
contact email | jw13@sanger.ac.uk |
dataset submitter | |
Full Dataset Link List
Dataset FTP location
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PRIDE project URI |
Repository Record List
[ + ]
[ - ]
- PRIDE
- PXD007781
- Label: PRIDE project
- Name: Massively parallel genetic resistance screens