PXD007773 is an
original dataset announced via ProteomeXchange.
Dataset Summary
Title | Experiment 03: Macaca mulatta infected with Plasmodium coatneyi Hackeri strain to produce and integrate clinical, hematological, parasitological, and omics measures of acute, recrudescent, and chronic infections. |
Description | Malaria-naive male rhesus macaques (Macaca mulatta), approximately four years of age, were inoculated intravenously with salivary gland sporozoites produced and isolated at the Centers for Disease Control and Prevention from multiple Anopheles species (An. dirus, An. gambiae, and An. stephensi) and then profiled for clinical, hematological, parasitological, immunological, functional genomic, lipidomic, proteomic, and metabolomic measurements. The experiment was designed for 100 days, and pre- and post-100 day periods to prepare subjects and administer curative treatments respectively. The anti-malarial drug artemether was subcuratively administered to all subjects at the initial peak of infection, one out of the five macaques received four additional subcurative treatments for subsequent recrudescence peaks. The experimental infection in one subject was ineffective but the macaque was followed-up for the same period of 100 days. The different clinical phases of the infection were clinically determined for each subject. Blood-stage curative doses of artemether were administered to all subjects at the end of the study. Capillary blood samples were collected daily for the measurement of CBCs, reticulocytes, and parasitemias. Capillary blood samples were collected every other day to obtain plasma for metabolomic analysis. Venous blood and bone marrow samples were collected at seven time points for functional genomic, proteomic, lipidomic, and immunological analyses. Within the MaHPIC, this project is known as 'Experiment 03'. This dataset also includes results from MaHPIC Experiment 18 (E18). LC-MS/MS output from E18 were used as a control for analysis. Refer to the E03 and E18 README files for details of these datasets and their production. |
HostingRepository | PRIDE |
AnnounceDate | 2024-10-22 |
AnnouncementXML | Submission_2024-10-22_04:55:37.397.xml |
DigitalObjectIdentifier | |
ReviewLevel | Peer-reviewed dataset |
DatasetOrigin | Original dataset |
RepositorySupport | Unsupported dataset by repository |
PrimarySubmitter | Jessica Kissinger |
SpeciesList | scientific name: Macaca mulatta (Rhesus macaque); NCBI TaxID: 9544; scientific name: Plasmodium coatneyi; NCBI TaxID: 208452; |
ModificationList | carbamoylated residue; monohydroxylated residue; acetylated residue; iodoacetamide derivatized residue; deamidated residue |
Instrument | Orbitrap Fusion |
Dataset History
Revision | Datetime | Status | ChangeLog Entry |
0 | 2017-09-18 05:26:38 | ID requested | |
1 | 2017-10-17 01:30:43 | announced | |
2 | 2017-10-18 07:17:18 | announced | Updated project metadata. |
⏵ 3 | 2024-10-22 04:55:37 | announced | 2024-10-22: Updated project metadata. |
Publication List
Dataset with its publication pending |
Keyword List
ProteomeXchange project tag: Malaria Host-Pathogen Interaction Center (MaHPIC) |
curator keyword: Biological, Biomedical |
submitter keyword: UGA, Artemether, Shotgun, MaHPIC,Malaria, Emory, Experiment 03, Systems Biology, Plasmodium coatneyi, Macaca mulatta |
Contact List
Mary R. Galinski |
contact affiliation | Emory University |
contact email | mahpic@emory.edu |
lab head | |
Jessica Kissinger |
contact affiliation | Institute of Bioinformatics, University of Georgia |
contact email | mahpic-infodepo@uga.edu |
dataset submitter | |
Full Dataset Link List
Dataset FTP location
NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2019/03/PXD007773 |
PRIDE project URI |
Repository Record List
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[ - ]
- PRIDE
- PXD007773
- Label: PRIDE project
- Name: Experiment 03: Macaca mulatta infected with Plasmodium coatneyi Hackeri strain to produce and integrate clinical, hematological, parasitological, and omics measures of acute, recrudescent, and chronic infections.