PXD007770

PXD007770 is an original dataset announced via ProteomeXchange.

Dataset Summary

Title	Effect of Sec61 inhibitor mycolactone on the proteome of the MED17.11 neuronal cell line
Description	Mycolactone is a mycobacteria-derived macrolide that blocks the biogenesis of a large array of secreted and transmembrane proteins through potent inhibition of the Sec61 translocon. Here, we used quantitative proteomics to delineate the direct and indirect effects of mycolactone-mediated Sec61 blockade on mouse on MED17.11 cells, as a model of dorsal root ganglia (DRG) sensory neurons, in resting and LPS-stimulated conditions. This analysis completes two previously reported ones, which investigated the effects of mycolactone on the proteome of the mouse MutuDC dendritic cells (Project PXD006103) and human Jurkat T cells (Project PXD002971).
HostingRepository	PRIDE
AnnounceDate	2024-10-22
AnnouncementXML	Submission_2024-10-22_04:39:50.386.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Jean-David Morel
SpeciesList	scientific name: Mus musculus (Mouse); NCBI TaxID: 10090;
ModificationList	L-methionine sulfoxide; acetylated residue; iodoacetamide derivatized residue
Instrument	Q Exactive HF

Dataset History

Revision	Datetime	Status	ChangeLog Entry
0	2017-09-18 05:08:42	ID requested
1	2018-06-26 08:46:57	announced
⏵ 2	2024-10-22 04:39:58	announced	2024-10-22: Updated project metadata.

Publication List

Morel JD, Paatero AO, Wei J, Yewdell JW, Guenin-Mac, é L, Van Haver D, Impens F, Pietrosemoli N, Paavilainen VO, Demangel C, Proteomics Reveals Scope of Mycolactone-mediated Sec61 Blockade and Distinctive Stress Signature. Mol Cell Proteomics, 17(9):1750-1765(2018) [pubmed]
10.1074/mcp.ra118.000824;

Morel JD, Paatero AO, Wei J, Yewdell JW, Guenin-Mac, é L, Van Haver D, Impens F, Pietrosemoli N, Paavilainen VO, Demangel C, Proteomics Reveals Scope of Mycolactone-mediated Sec61 Blockade and Distinctive Stress Signature. Mol Cell Proteomics, 17(9):1750-1765(2018) [pubmed]

10.1074/mcp.ra118.000824;

Keyword List

curator keyword: Biomedical
submitter keyword: Sec61, mycolactone, sensory neurons

curator keyword: Biomedical

submitter keyword: Sec61, mycolactone, sensory neurons

Contact List

Caroline Demangel
contact affiliation	Immunobiology of Infection Unit,Institut Pasteur, 75015 Paris, France
contact email	caroline.demangel@pasteur.fr
lab head
Jean-David Morel
contact affiliation	Institut Pasteur, Paris, France
contact email	jean-david.morel@pasteur.fr
dataset submitter

Full Dataset Link List

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2018/06/PXD007770
PRIDE project URI

Dataset FTP location
NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2018/06/PXD007770

PRIDE project URI

Repository Record List

[ + ]