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PXD007764

PXD007764 is an original dataset announced via ProteomeXchange.

Dataset Summary
TitleProteomic analysis of Naegleria gruberi mitochondria
DescriptionThe formation of mitochondria has enabled eukaryotes to thrive and evolve into multitude of unicellular and multicellular species. The nature of the early mitochondria and its relationship to the ancestral host cell is still unknown. Using a phylogenomic approach we have discovered the presence of core subunits of type II secretion pathway (T2SS) in several unicellular eukaryotes (protists) belonging to jakobids, hetereloboseans and malawimonads. We show that the proteins carry mitochondrial signal sequences and are localized in the protist mitochondria.The mitochondria of Nagleria gruberi were isolated by differential centrifugation and analysed by mass spectrometry. The data analyses revealed about 1000 proteins enriched in the mitochondrial fraction including the components of T2SS.
HostingRepositoryPRIDE
AnnounceDate2024-10-22
AnnouncementXMLSubmission_2024-10-22_05:22:08.662.xml
DigitalObjectIdentifier
ReviewLevelPeer-reviewed dataset
DatasetOriginOriginal dataset
RepositorySupportUnsupported dataset by repository
PrimarySubmitterKarel Harant
SpeciesList scientific name: Naegleria sp. NGES2; NCBI TaxID: 1437330;
ModificationListmethylthiolated residue
InstrumentOrbitrap Fusion
Dataset History
RevisionDatetimeStatusChangeLog Entry
02017-09-18 02:19:36ID requested
12021-05-19 07:37:43announced
22024-10-22 05:22:09announced2024-10-22: Updated project metadata.
Publication List
Dataset with its publication pending
Keyword List
curator keyword: Biological
submitter keyword: evolution,mitochondria, protist, type two secretion
Contact List
Mgr. Pavel Doležal, Ph.D.
contact affiliation„BIOCEV – Biotechnology and Biomedicine Centre of the Academy of Sciences and Charles University“ (CZ.1.05/1.1.00/02.0109)
contact emailpavel.dolezal@natur.cuni.cz
lab head
Karel Harant
contact affiliationCharles University
contact emailharant@natur.cuni.cz
dataset submitter
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Dataset FTP location
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PRIDE project URI
Repository Record List
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