PXD007763

PXD007763 is an original dataset announced via ProteomeXchange.

Title	Phosphorylation of iRhom2 controls stimulated proteolytic shedding by the metalloprotease ADAM17/TACE
Description	TACE (TNFa Converting Enzyme), is responsible for cleavage (‘shedding’) of membrane-tethered signaling molecules such as TNF of EGFR ligands. TACE interacts with iRhom2, which mediates the exit of TACE from the endoplasmic reticulum. In this study we analyze a new role for iRHOM2, where a fraction of the protein remains in the membrane and the phosphorylation of different residues in its cytoplasmatic tail is necessary for TACE shedding function.
HostingRepository	PRIDE
AnnounceDate	2021-11-03
AnnouncementXML	Submission_2021-11-03_05:43:29.597.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Alfonso Bolado
SpeciesList	scientific name: Homo sapiens (Human); NCBI TaxID: 9606;
ModificationList	carbamoylated residue; phosphorylated residue; monohydroxylated residue; acetylated residue
Instrument	Q Exactive

Revision	Datetime	Status	ChangeLog Entry
0	2017-09-18 02:10:43	ID requested
⏵ 1	2021-11-03 05:43:30	announced

Cavadas M, Oikonomidi I, Gaspar CJ, Burbridge E, Badenes M, F, é, lix I, Bolado A, Hu T, Bileck A, Gerner C, Domingos PM, von Kriegsheim A, Adrain C, Phosphorylation of iRhom2 Controls Stimulated Proteolytic Shedding by the Metalloprotease ADAM17/TACE. Cell Rep, 21(3):745-757(2017) [pubmed]

curator keyword: Biological

submitter keyword: iRHOM2 TACE phosphorylation

Alexander von Kriegsheim
contact affiliation	Cancer Research UK Edinburgh Centre MRC Institute of Genetics & Molecular Medicine The University of Edinburgh Western General Hospital Crewe Road South, Edinburgh EH4 2XR
contact email	Alex.VonKriegsheim@igmm.ed.ac.uk
lab head
Alfonso Bolado
contact affiliation	University of Edinburgh
contact email	Alfonso.Bolado@igmm.ed.ac.uk
dataset submitter

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2021/11/PXD007763

PRIDE project URI

• PRIDE
  1. PXD007763
     1. Label: PRIDE project
     2. Name: Phosphorylation of iRhom2 controls stimulated proteolytic shedding by the metalloprotease ADAM17/TACE