PXD007754

PXD007754 is an original dataset announced via ProteomeXchange.

Title	Lupus Nephritis is characterized by defective removal of Neutrophil Extracellular Traps that are modified in protein composition and contain specific auto-antigens.
Description	Neutrophyl Extracellular Traps (NETs) accumulated in serum of patients with Lupus Nephritis for defective removal by DNAse. Among a complex protein panel (overall 802) two clusters of 16 and 13 proteins were more expressed by LN and SLE NETs respectively; oxidized aenolase and annexin A1 were main components of the first series in LN. NETs may represent a source of modified intracellular antigens for autoimmunity in LN.
HostingRepository	PRIDE
AnnounceDate	2024-10-22
AnnouncementXML	Submission_2024-10-22_04:40:50.472.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Chiara Lavarello
SpeciesList	scientific name: Homo sapiens (Human); NCBI TaxID: 9606;
ModificationList	phosphorylated residue; monohydroxylated residue; acetylated residue; iodoacetamide derivatized residue
Instrument	Q Exactive

Revision	Datetime	Status	ChangeLog Entry
0	2017-09-18 01:31:59	ID requested
1	2019-11-14 00:46:35	announced
⏵ 2	2024-10-22 04:40:55	announced	2024-10-22: Updated project metadata.

10.1038/s41598-019-44379-w;

Bruschi M, Petretto A, Santucci L, Vaglio A, Pratesi F, Migliorini P, Bertelli R, Lavarello C, Bartolucci M, Candiano G, Prunotto M, Ghiggeri GM, enolase (methionine sulfoxide 93). Sci Rep, 9(1):7934(2019) [pubmed]

curator keyword: Biomedical

submitter keyword: HUMAN, PROTEOMICS, Lupus Nephritis, LC-MS/MS

Andrea Petretto
contact affiliation	Istituto G.Gaslini
contact email	andreapetretto@gaslini.org
lab head
Chiara Lavarello
contact affiliation	Istituto G.Gaslini
contact email	chiaralavarello@ospedale-gaslini.ge.it
dataset submitter

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2019/11/PXD007754

PRIDE project URI

• PRIDE
  1. PXD007754
     1. Label: PRIDE project
     2. Name: Lupus Nephritis is characterized by defective removal of Neutrophil Extracellular Traps that are modified in protein composition and contain specific auto-antigens.