PXD007752

PXD007752 is an original dataset announced via ProteomeXchange.

Dataset Summary

Title	Identification of the covalent binding site of Ibrutinib and 5Z-7-Oxozeaenol to ZAK
Description	The goal of this experiment was to identify the reaction site of Ibrutinib and 5Z-7-Oxozeaenol to ZAK by determination of mass shifts according to a covalent modification by the inhibitors using mass spectrometry.
HostingRepository	PRIDE
AnnounceDate	2024-10-22
AnnouncementXML	Submission_2024-10-22_04:40:46.027.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Maria Faelth Savitski
SpeciesList	scientific name: Homo sapiens (Human); NCBI TaxID: 9606;
ModificationList	monohydroxylated residue; acetylated residue; iodoacetamide derivatized residue
Instrument	Q Exactive

Dataset History

Revision	Datetime	Status	ChangeLog Entry
0	2017-09-18 01:24:37	ID requested
1	2017-10-13 05:43:20	announced
⏵ 2	2024-10-22 04:40:50	announced	2024-10-22: Updated project metadata.

Publication List

10.1021/acschembio.7b00617;
Dittus L, Werner T, Muelbaier M, Bantscheff M, Differential Kinobeads Profiling for Target Identification of Irreversible Kinase Inhibitors. ACS Chem Biol, 12(10):2515-2521(2017) [pubmed]

10.1021/acschembio.7b00617;

Dittus L, Werner T, Muelbaier M, Bantscheff M, Differential Kinobeads Profiling for Target Identification of Irreversible Kinase Inhibitors. ACS Chem Biol, 12(10):2515-2521(2017) [pubmed]

Keyword List

curator keyword: Biological, Biomedical
submitter keyword: Ibrutinib, 5Z-7-Oxozeaenol, Cys150,Recombinant ZAK, Cys22, covalent modification

curator keyword: Biological, Biomedical

submitter keyword: Ibrutinib, 5Z-7-Oxozeaenol, Cys150,Recombinant ZAK, Cys22, covalent modification

Contact List

Marcus Bantscheff
contact affiliation	Cellzome
contact email	marcus.x.bantscheff@gsk.com
lab head
Maria Faelth Savitski
contact affiliation	Cellzome
contact email	maria.x.faelth-savitski@gsk.com
dataset submitter

Full Dataset Link List

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2017/10/PXD007752
PRIDE project URI

Dataset FTP location
NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2017/10/PXD007752

PRIDE project URI

Repository Record List

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