PXD007743

PXD007743 is an original dataset announced via ProteomeXchange.

Title	Two cancer-promoting stromal gene expression programs depend on lung function
Description	Chronic obstructive pulmonary disease (COPD) is an independent risk factor for lung cancer, suggesting that COPD stroma favors cancer initiation. Therefore, we used proteomics and polysome-profiling to identify gene expression programs that distinguish stroma of patients harboring lung cancer from those that do not, with varied COPD severities. This profiling unveiled distinct COPD-dependent cancer-associated gene expression programs predominantly manifesting as alterations in mRNA translation. Mechanistically, such programs are downstream of the mammalian target of rapamycin pathway in mild COPD and pathological extracellular matrix in more severe COPD; and both programs parallel activation of distinct pro-cancer fibroblast-derived secretomes. Therefore, depending upon COPD severity, the lung stroma can exist in two states favoring cancer initiation, which likely result in distinct disease entities.
HostingRepository	PRIDE
AnnounceDate	2024-10-22
AnnouncementXML	Submission_2024-10-22_05:30:00.536.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Brian Sandri
SpeciesList	scientific name: Homo sapiens (Human); NCBI TaxID: 9606;
ModificationList	iTRAQ8plex-116 reporter+balance reagent acylated residue; monohydroxylated residue
Instrument	LTQ Orbitrap Velos

Revision	Datetime	Status	ChangeLog Entry
0	2017-09-15 01:06:04	ID requested
1	2021-11-03 02:35:22	announced
⏵ 2	2024-10-22 05:30:01	announced	2024-10-22: Updated project metadata.

Sandri BJ, Kaplan A, Hodgson SW, Peterson M, Avdulov S, Higgins L, Markowski T, Yang P, Limper AH, Griffin TJ, Bitterman P, Lock EF, Wendt CH, Multi-omic molecular profiling of lung cancer in COPD. Eur Respir J, 52(1):(2018) [pubmed]

10.1183/13993003.02665-2017;

curator keyword: Biomedical

submitter keyword: Human, Translatomics, COPD, Lung Tissue, Transcriptomics, Proteomics, Emphysema, Lung Cancer

Chris Wendt
contact affiliation	Pulmonary, Allergy, Critical Care, and Sleep Division Medicine Department University of Minnesota - TC Minneapolis, MN
contact email	wendt005@umn.edu
lab head
Brian Sandri
contact affiliation	University of Minnesota
contact email	sand0449@umn.edu
dataset submitter

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2021/11/PXD007743

PRIDE project URI

• PRIDE
  1. PXD007743
     1. Label: PRIDE project
     2. Name: Two cancer-promoting stromal gene expression programs depend on lung function