PXD007741 is an
original dataset announced via ProteomeXchange.
Dataset Summary
Title | Identifying host factors associated with DNA replicated during virus infection |
Description | Viral DNA genomes replicating in cells encounter a myriad of host factors that facilitate or hinder viral replication. Viral proteins expressed early during infection modulate host factors interacting with viral genomes, recruiting proteins to promote viral replication, and limiting access to antiviral repressors. Although some host factors manipulated by viruses have been identified, we know little about pathways exploited during infection and how these differ between viruses. To identify cellular processes manipulated during viral replication, we defined proteomes associated with viral genomes during infection with adenovirus, herpes simplex virus and vaccinia virus. We compared enrichment of host factors between virus proteomes and confirmed association with viral genomes and replication compartments. Using adenovirus as an illustrative example, we uncovered host factors deactivated by early viral proteins, and identified a subgroup of nucleolar proteins that aid virus replication. Our datasets provide valuable resources of virus-host interactions that affect proteins on viral genomes. |
HostingRepository | PRIDE |
AnnounceDate | 2024-10-22 |
AnnouncementXML | Submission_2024-10-22_04:40:36.475.xml |
DigitalObjectIdentifier | |
ReviewLevel | Peer-reviewed dataset |
DatasetOrigin | Original dataset |
RepositorySupport | Unsupported dataset by repository |
PrimarySubmitter | Katarzyna Kulej |
SpeciesList | scientific name: Herpesvirales; NCBI TaxID: 548681; scientific name: Vaccinia virus WR; NCBI TaxID: 10254; scientific name: Human adenovirus C serotype 5 (HAdV-5) (Human adenovirus 5); NCBI TaxID: 28285; scientific name: Homo sapiens (Human); NCBI TaxID: 9606; |
ModificationList | mono N-acetylated residue; monohydroxylated residue; iodoacetamide derivatized residue |
Instrument | LTQ Orbitrap Elite |
Dataset History
Revision | Datetime | Status | ChangeLog Entry |
0 | 2017-09-14 01:55:51 | ID requested | |
1 | 2017-10-05 00:14:36 | announced | |
⏵ 2 | 2024-10-22 04:40:44 | announced | 2024-10-22: Updated project metadata. |
Publication List
Reyes ED, Kulej K, Pancholi NJ, Akhtar LN, Avgousti DC, Kim ET, Bricker DK, Spruce LA, Koniski SA, Seeholzer SH, Isaacs SN, Garcia BA, Weitzman MD, Identifying Host Factors Associated with DNA Replicated During Virus Infection. Mol Cell Proteomics, 16(12):2079-2097(2017) [pubmed] |
10.1074/mcp.m117.067116; |
Keyword List
curator keyword: Biological |
submitter keyword: virus infection / DNA replication / DNA repair / intrinsic defense |
Contact List
Matthew D. Weitzman |
contact affiliation | Department of Pathology and Laboratory Medicine,University of Pennsylvania Perelman School of Medicine, Philadelphia, PA USA Division of Cancer Pathobiology,Children's Hospital of Philadelphia, Philadelphia, PA USA |
contact email | weitzmanm@email.chop.edu |
lab head | |
Katarzyna Kulej |
contact affiliation | Children's Hospital of Philadelphia |
contact email | kulej.katarzyna@gmail.com |
dataset submitter | |
Full Dataset Link List
Dataset FTP location
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PRIDE project URI |
Repository Record List
[ + ]
[ - ]
- PRIDE
- PXD007741
- Label: PRIDE project
- Name: Identifying host factors associated with DNA replicated during virus infection