PXD007708 is an
original dataset announced via ProteomeXchange.
Dataset Summary
Title | Delineating the Rb1 interactome data and its modulations during cell cycle progression. |
Description | The retinoblastoma (Rb) protein is a potent tumor suppressor which is known to negatively regulate the cell cycle as well as tumor progression. Phosphorylated Rb protein (pRb) has been demonstrated to be in-charge for the key G1 checkpoint, blocking entry into S-phase and thereby the cell growth. This study was designed to capture interacting protein partners of Rb1 as the cell cycle progresses. Rb1 expressing HEK-293 cells were cultured in light, medium and heavy SILAC labels to capture the changes in Rb1 interactome as the cell cycle progressed from G0 to G1S and then to G2 phase, respectively. This data might help in understanding the cell cycle regulatory effect of Rb1 protein and complement the available information on its interacting partners. |
HostingRepository | PRIDE |
AnnounceDate | 2017-09-14 |
AnnouncementXML | Submission_2017-09-14_02:05:27.xml |
DigitalObjectIdentifier | |
ReviewLevel | Peer-reviewed dataset |
DatasetOrigin | Original dataset |
RepositorySupport | Unsupported dataset by repository |
PrimarySubmitter | Shweta Duggal |
SpeciesList | scientific name: Homo sapiens (Human); NCBI TaxID: 9606; |
ModificationList | 6x(13)C labeled residue |
Instrument | TripleTOF 5600 |
Dataset History
Revision | Datetime | Status | ChangeLog Entry |
0 | 2017-09-11 01:37:52 | ID requested | |
⏵ 1 | 2017-09-14 02:05:28 | announced | |
Publication List
Dataset with its publication pending |
Keyword List
curator keyword: Biological, Biomedical |
submitter keyword: Rb1, cell cycle, Interactome, SILAC, AP-MS, Tumor suppressor |
Contact List
Kanury V.S. Rao |
contact affiliation | THSTI - National Chair and Head, Drug Discovery Research Centre Translational Health Science and Technology Institute, Faridabad, INDIA |
contact email | kanury@thsti.res.in |
lab head | |
Shweta Duggal |
contact affiliation | ICGEB and THSTI |
contact email | dshweta88@gmail.com |
dataset submitter | |
Full Dataset Link List
Dataset FTP location
NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2017/09/PXD007708 |
PRIDE project URI |
Repository Record List
[ + ]
[ - ]
- PRIDE
- PXD007708
- Label: PRIDE project
- Name: Delineating the Rb1 interactome data and its modulations during cell cycle progression.