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PXD007708

PXD007708 is an original dataset announced via ProteomeXchange.

Dataset Summary
TitleDelineating the Rb1 interactome data and its modulations during cell cycle progression.
DescriptionThe retinoblastoma (Rb) protein is a potent tumor suppressor which is known to negatively regulate the cell cycle as well as tumor progression. Phosphorylated Rb protein (pRb) has been demonstrated to be in-charge for the key G1 checkpoint, blocking entry into S-phase and thereby the cell growth. This study was designed to capture interacting protein partners of Rb1 as the cell cycle progresses. Rb1 expressing HEK-293 cells were cultured in light, medium and heavy SILAC labels to capture the changes in Rb1 interactome as the cell cycle progressed from G0 to G1S and then to G2 phase, respectively. This data might help in understanding the cell cycle regulatory effect of Rb1 protein and complement the available information on its interacting partners.
HostingRepositoryPRIDE
AnnounceDate2017-09-14
AnnouncementXMLSubmission_2017-09-14_02:05:27.xml
DigitalObjectIdentifier
ReviewLevelPeer-reviewed dataset
DatasetOriginOriginal dataset
RepositorySupportUnsupported dataset by repository
PrimarySubmitterShweta Duggal
SpeciesList scientific name: Homo sapiens (Human); NCBI TaxID: 9606;
ModificationList6x(13)C labeled residue
InstrumentTripleTOF 5600
Dataset History
RevisionDatetimeStatusChangeLog Entry
02017-09-11 01:37:52ID requested
12017-09-14 02:05:28announced
Publication List
Dataset with its publication pending
Keyword List
curator keyword: Biological, Biomedical
submitter keyword: Rb1, cell cycle, Interactome, SILAC, AP-MS, Tumor suppressor
Contact List
Kanury V.S. Rao
contact affiliationTHSTI - National Chair and Head, Drug Discovery Research Centre Translational Health Science and Technology Institute, Faridabad, INDIA
contact emailkanury@thsti.res.in
lab head
Shweta Duggal
contact affiliationICGEB and THSTI
contact emaildshweta88@gmail.com
dataset submitter
Full Dataset Link List
Dataset FTP location
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PRIDE project URI
Repository Record List
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