PXD007708

PXD007708 is an original dataset announced via ProteomeXchange.

Title	Delineating the Rb1 interactome data and its modulations during cell cycle progression.
Description	The retinoblastoma (Rb) protein is a potent tumor suppressor which is known to negatively regulate the cell cycle as well as tumor progression. Phosphorylated Rb protein (pRb) has been demonstrated to be in-charge for the key G1 checkpoint, blocking entry into S-phase and thereby the cell growth. This study was designed to capture interacting protein partners of Rb1 as the cell cycle progresses. Rb1 expressing HEK-293 cells were cultured in light, medium and heavy SILAC labels to capture the changes in Rb1 interactome as the cell cycle progressed from G0 to G1S and then to G2 phase, respectively. This data might help in understanding the cell cycle regulatory effect of Rb1 protein and complement the available information on its interacting partners.
HostingRepository	PRIDE
AnnounceDate	2017-09-14
AnnouncementXML	Submission_2017-09-14_02:05:27.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Shweta Duggal
SpeciesList	scientific name: Homo sapiens (Human); NCBI TaxID: 9606;
ModificationList	6x(13)C labeled residue
Instrument	TripleTOF 5600

Revision	Datetime	Status	ChangeLog Entry
0	2017-09-11 01:37:52	ID requested
⏵ 1	2017-09-14 02:05:28	announced

Dataset with its publication pending

curator keyword: Biological, Biomedical

submitter keyword: Rb1, cell cycle, Interactome, SILAC, AP-MS, Tumor suppressor

Kanury V.S. Rao
contact affiliation	THSTI - National Chair and Head, Drug Discovery Research Centre Translational Health Science and Technology Institute, Faridabad, INDIA
contact email	kanury@thsti.res.in
lab head
Shweta Duggal
contact affiliation	ICGEB and THSTI
contact email	dshweta88@gmail.com
dataset submitter

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2017/09/PXD007708

PRIDE project URI

• PRIDE
  1. PXD007708
     1. Label: PRIDE project
     2. Name: Delineating the Rb1 interactome data and its modulations during cell cycle progression.