PXD007690 is an
original dataset announced via ProteomeXchange.
Dataset Summary
Title | Effect of Juvenile Environmental Tobacco Smoke Exposure on the Rat Frontal Cortex Neuroproteome |
Description | Exposure to secondhand tobacco smoke during early childhood has been linked with an increased risk for behavioral disorders, yet little is known regarding how brain development is impacted. Using an environmental tobacco smoke (ETS) passive inhalation model, this study assesses the neurodevelopmental impact of juvenile exposure during a critical period of frontal cortex development, specifically that of the rat orbital neocortex between postnatal days 8 and 22. Agnostic shotgun proteomics was employed to discern the biomolecular shift within this rapidly developing brain region that is responsible for higher-order behavioral control. The orbital cortex neuroproteome was assessed between ETS-exposed and room-air control animals employing a label-free shotgun approach with data-independent acquisition. Following protein roll-up, a total of X protein were found statistically altered in quantity out of Y total proteins identified. These results implicate a prominent shift within metabolic processes and synaptic organization related to excitatory and inhibitory neurotransmission. Findings derived from this dataset may further our understanding of how secondhand smoke exposure can perturb the orbital frontal cortex and result in developmental behavioral disorders. |
HostingRepository | PRIDE |
AnnounceDate | 2020-05-26 |
AnnouncementXML | Submission_2020-05-26_13:13:13.xml |
DigitalObjectIdentifier | https://dx.doi.org/10.6019/PXD007690 |
ReviewLevel | Peer-reviewed dataset |
DatasetOrigin | Original dataset |
RepositorySupport | Supported dataset by repository |
PrimarySubmitter | Andrew Ottens |
SpeciesList | scientific name: Rattus norvegicus (Rat); NCBI TaxID: 10116; |
ModificationList | Phospho; Methyl; Oxidation; Carbamidomethyl |
Instrument | Synapt G2 HDMS |
Dataset History
Revision | Datetime | Status | ChangeLog Entry |
0 | 2017-09-07 04:11:44 | ID requested | |
⏵ 1 | 2020-05-26 13:13:14 | announced | |
Publication List
Lewis LSC, Muldoon PP, Pilaka PP, Ottens AK, Frontal Cortex Proteome Perturbation after Juvenile Rat Secondhand Smoke Exposure. Proteomics, 18(24):e1800268(2018) [pubmed] |
Keyword List
curator keyword: Biological |
submitter keyword: at, Brain, Frontal, Cortex, Juvenile, Development, Neuroproteome, HDMSe, Secondhand Smoke, tobacco |
Contact List
Andrew K Ottens |
contact affiliation | Department of Anatomy and Neurobiology, School of Medicine, Virginia Commonwealth University, Richmond, VA USA |
contact email | akottens@vcu.edu |
lab head | |
Andrew Ottens |
contact affiliation | Virginia Commonwealth University |
contact email | akottens@vcu.edu |
dataset submitter | |
Full Dataset Link List
Dataset FTP location
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PRIDE project URI |
Repository Record List
[ + ]
[ - ]
- PRIDE
- PXD007690
- Label: PRIDE project
- Name: Effect of Juvenile Environmental Tobacco Smoke Exposure on the Rat Frontal Cortex Neuroproteome