PXD007680

PXD007680 is an original dataset announced via ProteomeXchange.

Title	Argentilactone molecular targets in Paracoccidioides brasiliensis identified by chemoproteomics
Description	The etiological agents of PCM belong to the Paracoccidioides genus, which is restricted to Latin America. The infection is acquired through inhalation of conidia that primarily lodge in the lungs and may disseminate to other organs/tissues. Treatment of PCM is commonly achieved via administration of antifungals of the azole class, sulfonamides, and amphotericin B. The antifungal toxicity and side effects, added to the long treatment time has driven research for new bioactive compounds. Argentilactone, compound isolated from a Brazilian savanna plant Hyptis ovaliofolia, has been suggested as potent antifungal, inhibiting dimorphism of P. brasiliensis and the enzymatic activity of isocitrate lyase, a key enzyme of the glyoxylate cycle. Furthermore, it has no cytotoxicity and genotoxicity in fibroblast cells at concentrations that inhibit the fungal growth. This work was developed due to the importance of elucidating the putative mode of action of argentilactone. The chemoproteomics approach, by affinity chromatography, was the methodology used to explore the interactions between P. brasiliensis proteins and argentilactone
HostingRepository	PRIDE
AnnounceDate	2018-02-07
AnnouncementXML	Submission_2019-03-07_05:46:47.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Lívia Do Carmo Silva
SpeciesList	scientific name: Paracoccidioides brasiliensis (strain Pb18); NCBI TaxID: 502780;
ModificationList	No PTMs are included in the dataset
Instrument	nanoACQUITY UPLC

Revision	Datetime	Status	ChangeLog Entry
0	2017-09-06 08:36:57	ID requested
1	2018-02-07 15:17:44	announced
⏵ 2	2019-03-07 05:46:48	announced	Updated publication reference for PubMed record(s): 30150478.

Silva LDC, Tauhata SBF, Baeza LC, de Oliveira CMA, Kato L, Borges CL, de Almeida Soares CM, Pereira M, Argentilactone Molecular Targets in Paracoccidioides brasiliensis Identified by Chemoproteomics. Antimicrob Agents Chemother, 62(11):(2018) [pubmed]

curator keyword: Biological

submitter keyword: Paracoccidioides, antifungal, targets, argentilactone, chemoproteomics

Lívia do Carmo Silva
contact affiliation	Biochemistry and molecular biology department, Universidade Federal de Goias, Brazil
contact email	livia.lbm.ufg@gmail.com
lab head
Lívia Do Carmo Silva
contact affiliation	Universidade Federal de Goiás
contact email	livia.lbm.ufg@gmail.com
dataset submitter

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2018/02/PXD007680

PRIDE project URI

• PRIDE
  1. PXD007680
     1. Label: PRIDE project
     2. Name: Argentilactone molecular targets in Paracoccidioides brasiliensis identified by chemoproteomics