PXD007638 is an
original dataset announced via ProteomeXchange.
Dataset Summary
Title | Confirmation of ZAK as covalent target of Ibrutinib |
Description | The goal of this experiment was the confirmation of ZAK as a covalent target of Ibrutinib by an affinity enrichment experiment with a linkable analogue of Ibrutinib. |
HostingRepository | PRIDE |
AnnounceDate | 2024-10-22 |
AnnouncementXML | Submission_2024-10-22_04:40:09.247.xml |
DigitalObjectIdentifier | |
ReviewLevel | Peer-reviewed dataset |
DatasetOrigin | Original dataset |
RepositorySupport | Unsupported dataset by repository |
PrimarySubmitter | Maria Faelth Savitski |
SpeciesList | scientific name: Homo sapiens (Human); NCBI TaxID: 9606; |
ModificationList | TMT6plex-126 reporter+balance reagent acylated residue; monohydroxylated residue; acetylated residue; iodoacetamide derivatized residue |
Instrument | Q Exactive |
Dataset History
Revision | Datetime | Status | ChangeLog Entry |
0 | 2017-09-04 01:47:53 | ID requested | |
1 | 2017-10-13 05:00:43 | announced | |
⏵ 2 | 2024-10-22 04:40:10 | announced | 2024-10-22: Updated project metadata. |
Publication List
10.1021/acschembio.7b00617; |
Dittus L, Werner T, Muelbaier M, Bantscheff M, Differential Kinobeads Profiling for Target Identification of Irreversible Kinase Inhibitors. ACS Chem Biol, 12(10):2515-2521(2017) [pubmed] |
Keyword List
curator keyword: Biomedical |
submitter keyword: lysate-based assay, linkable Ibrutinib affinity enrichment, SDS elution vs bead trypsinationLC-MS/MS,Ibrutinib, Ramos B-lymphocyte lysate |
Contact List
Marcus Bantscheff |
contact affiliation | Cellzome |
contact email | marcus.x.bantscheff@gsk.com |
lab head | |
Maria Faelth Savitski |
contact affiliation | Cellzome |
contact email | maria.x.faelth-savitski@gsk.com |
dataset submitter | |
Full Dataset Link List
Dataset FTP location
NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2017/10/PXD007638 |
PRIDE project URI |
Repository Record List
[ + ]
[ - ]
- PRIDE
- PXD007638
- Label: PRIDE project
- Name: Confirmation of ZAK as covalent target of Ibrutinib