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PXD007638

PXD007638 is an original dataset announced via ProteomeXchange.

Dataset Summary
TitleConfirmation of ZAK as covalent target of Ibrutinib
DescriptionThe goal of this experiment was the confirmation of ZAK as a covalent target of Ibrutinib by an affinity enrichment experiment with a linkable analogue of Ibrutinib.
HostingRepositoryPRIDE
AnnounceDate2024-10-22
AnnouncementXMLSubmission_2024-10-22_04:40:09.247.xml
DigitalObjectIdentifier
ReviewLevelPeer-reviewed dataset
DatasetOriginOriginal dataset
RepositorySupportUnsupported dataset by repository
PrimarySubmitterMaria Faelth Savitski
SpeciesList scientific name: Homo sapiens (Human); NCBI TaxID: 9606;
ModificationListTMT6plex-126 reporter+balance reagent acylated residue; monohydroxylated residue; acetylated residue; iodoacetamide derivatized residue
InstrumentQ Exactive
Dataset History
RevisionDatetimeStatusChangeLog Entry
02017-09-04 01:47:53ID requested
12017-10-13 05:00:43announced
22024-10-22 04:40:10announced2024-10-22: Updated project metadata.
Publication List
10.1021/acschembio.7b00617;
Dittus L, Werner T, Muelbaier M, Bantscheff M, Differential Kinobeads Profiling for Target Identification of Irreversible Kinase Inhibitors. ACS Chem Biol, 12(10):2515-2521(2017) [pubmed]
Keyword List
curator keyword: Biomedical
submitter keyword: lysate-based assay, linkable Ibrutinib affinity enrichment, SDS elution vs bead trypsinationLC-MS/MS,Ibrutinib, Ramos B-lymphocyte lysate
Contact List
Marcus Bantscheff
contact affiliationCellzome
contact emailmarcus.x.bantscheff@gsk.com
lab head
Maria Faelth Savitski
contact affiliationCellzome
contact emailmaria.x.faelth-savitski@gsk.com
dataset submitter
Full Dataset Link List
Dataset FTP location
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PRIDE project URI
Repository Record List
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