PXD007638

PXD007638 is an original dataset announced via ProteomeXchange.

Dataset Summary

Title	Confirmation of ZAK as covalent target of Ibrutinib
Description	The goal of this experiment was the confirmation of ZAK as a covalent target of Ibrutinib by an affinity enrichment experiment with a linkable analogue of Ibrutinib.
HostingRepository	PRIDE
AnnounceDate	2024-10-22
AnnouncementXML	Submission_2024-10-22_04:40:09.247.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Maria Faelth Savitski
SpeciesList	scientific name: Homo sapiens (Human); NCBI TaxID: 9606;
ModificationList	TMT6plex-126 reporter+balance reagent acylated residue; monohydroxylated residue; acetylated residue; iodoacetamide derivatized residue
Instrument	Q Exactive

Dataset History

Revision	Datetime	Status	ChangeLog Entry
0	2017-09-04 01:47:53	ID requested
1	2017-10-13 05:00:43	announced
⏵ 2	2024-10-22 04:40:10	announced	2024-10-22: Updated project metadata.

Publication List

10.1021/acschembio.7b00617;
Dittus L, Werner T, Muelbaier M, Bantscheff M, Differential Kinobeads Profiling for Target Identification of Irreversible Kinase Inhibitors. ACS Chem Biol, 12(10):2515-2521(2017) [pubmed]

10.1021/acschembio.7b00617;

Dittus L, Werner T, Muelbaier M, Bantscheff M, Differential Kinobeads Profiling for Target Identification of Irreversible Kinase Inhibitors. ACS Chem Biol, 12(10):2515-2521(2017) [pubmed]

Keyword List

curator keyword: Biomedical
submitter keyword: lysate-based assay, linkable Ibrutinib affinity enrichment, SDS elution vs bead trypsinationLC-MS/MS,Ibrutinib, Ramos B-lymphocyte lysate

curator keyword: Biomedical

submitter keyword: lysate-based assay, linkable Ibrutinib affinity enrichment, SDS elution vs bead trypsinationLC-MS/MS,Ibrutinib, Ramos B-lymphocyte lysate

Contact List

Marcus Bantscheff
contact affiliation	Cellzome
contact email	marcus.x.bantscheff@gsk.com
lab head
Maria Faelth Savitski
contact affiliation	Cellzome
contact email	maria.x.faelth-savitski@gsk.com
dataset submitter

Full Dataset Link List

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2017/10/PXD007638
PRIDE project URI

Dataset FTP location
NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2017/10/PXD007638

PRIDE project URI

Repository Record List

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