PXD007598

PXD007598 is an original dataset announced via ProteomeXchange.

Title	Global analysis of protein degradation rates in primary rodent skin fibroblasts
Description	Within individual species and cell types, the range of protein turnover rates can span multiple orders of magnitude. However, it is not known if turnover kinetics of individual proteins are highly conserved or if they have evolved to meet the physiological demands of individual species. We have conducted systematic analyses of proteome turnover kinetics in primary dermal fibroblasts isolated from eight different rodent species. Our results demonstrate that protein turnover rates are generally well conserved across species but gradually deviate as a function of evolutionary distance.
HostingRepository	PRIDE
AnnounceDate	2024-10-22
AnnouncementXML	Submission_2024-10-22_04:01:26.409.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Kyle Swovick
SpeciesList	scientific name: Mus musculus (Mouse); NCBI TaxID: 10090; scientific name: Nannospalax galili; NCBI TaxID: 1026970; scientific name: Heterocephalus glaber; NCBI TaxID: 10181; scientific name: Rattus norvegicus (Rat); NCBI TaxID: 10116; scientific name: Chinchilla lanigera; NCBI TaxID: 34839; scientific name: Castor canadensis; NCBI TaxID: 51338; scientific name: Cavia porcellus (Guinea pig); NCBI TaxID: 10141;
ModificationList	6x(13)C labeled residue; acetylated residue
Instrument	Q Exactive

Revision	Datetime	Status	ChangeLog Entry
0	2017-08-30 05:10:25	ID requested
1	2018-02-09 11:42:39	announced
⏵ 2	2024-10-22 04:01:26	announced	2024-10-22: Updated project metadata.

Dataset with its publication pending

curator keyword: Biological

submitter keyword: dynamic stable isotope labeling in cell culture (SILAC), protein turnover, protein degradation, proteostasis,quantitative proteomics

Sina Ghaemmaghami
contact affiliation	Department of Biologyy, University of Rochester, NY, USA University of Rochester Mass Spectrometry Resource Laboratory, NY, USA
contact email	sghaemma@bio.rochester.edu
lab head
Kyle Swovick
contact affiliation	University of Rochester Medical Center Mass Spectrometry Shared Resource Laboratory
contact email	kswovick@ur.rochester.edu
dataset submitter

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2018/02/PXD007598

PRIDE project URI

• PRIDE
  1. PXD007598
     1. Label: PRIDE project
     2. Name: Global analysis of protein degradation rates in primary rodent skin fibroblasts