PXD007598 is an
original dataset announced via ProteomeXchange.
Dataset Summary
Title | Global analysis of protein degradation rates in primary rodent skin fibroblasts |
Description | Within individual species and cell types, the range of protein turnover rates can span multiple orders of magnitude. However, it is not known if turnover kinetics of individual proteins are highly conserved or if they have evolved to meet the physiological demands of individual species. We have conducted systematic analyses of proteome turnover kinetics in primary dermal fibroblasts isolated from eight different rodent species. Our results demonstrate that protein turnover rates are generally well conserved across species but gradually deviate as a function of evolutionary distance. |
HostingRepository | PRIDE |
AnnounceDate | 2024-10-22 |
AnnouncementXML | Submission_2024-10-22_04:01:26.409.xml |
DigitalObjectIdentifier | |
ReviewLevel | Peer-reviewed dataset |
DatasetOrigin | Original dataset |
RepositorySupport | Unsupported dataset by repository |
PrimarySubmitter | Kyle Swovick |
SpeciesList | scientific name: Mus musculus (Mouse); NCBI TaxID: 10090; scientific name: Nannospalax galili; NCBI TaxID: 1026970; scientific name: Heterocephalus glaber; NCBI TaxID: 10181; scientific name: Rattus norvegicus (Rat); NCBI TaxID: 10116; scientific name: Chinchilla lanigera; NCBI TaxID: 34839; scientific name: Castor canadensis; NCBI TaxID: 51338; scientific name: Cavia porcellus (Guinea pig); NCBI TaxID: 10141; |
ModificationList | 6x(13)C labeled residue; acetylated residue |
Instrument | Q Exactive |
Dataset History
Revision | Datetime | Status | ChangeLog Entry |
0 | 2017-08-30 05:10:25 | ID requested | |
1 | 2018-02-09 11:42:39 | announced | |
⏵ 2 | 2024-10-22 04:01:26 | announced | 2024-10-22: Updated project metadata. |
Publication List
Dataset with its publication pending |
Keyword List
curator keyword: Biological |
submitter keyword: dynamic stable isotope labeling in cell culture (SILAC), protein turnover, protein degradation, proteostasis,quantitative proteomics |
Contact List
Sina Ghaemmaghami |
contact affiliation | Department of Biologyy, University of Rochester, NY, USA University of Rochester Mass Spectrometry Resource Laboratory, NY, USA |
contact email | sghaemma@bio.rochester.edu |
lab head | |
Kyle Swovick |
contact affiliation | University of Rochester Medical Center Mass Spectrometry Shared Resource Laboratory |
contact email | kswovick@ur.rochester.edu |
dataset submitter | |
Full Dataset Link List
Dataset FTP location
NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2018/02/PXD007598 |
PRIDE project URI |
Repository Record List
[ + ]
[ - ]
- PRIDE
- PXD007598
- Label: PRIDE project
- Name: Global analysis of protein degradation rates in primary rodent skin fibroblasts