PXD007571

PXD007571 is an original dataset announced via ProteomeXchange.

Dataset Summary

Title	Rat-bladder-OAB - Proteomic analysis of urothelium of rats with detrusor overactivity induced by bladder outlet obstruction
Description	Overactive bladder (OAB) syndrome is a condition that has four symptoms: urgency, urinary frequency, nocturia, and urge incontinence and negatively affects a patient’s life. Recently, it is considered that the urinary bladder urothelium is closely linked to pathogenesis of OAB. However, the mechanisms of pathogenesis of OAB at the molecular level remain poorly understood, mainly as a result of lack of modern molecular analysis. The goal of this study is to identify a potential target protein that could act as a predictive factor for effective diagnosis and aid in the development of therapeutic strategies for the treatment of OAB syndrome. We produced OAB in a rat model and performed the first proteomic analysis on the mucosal layer (urothelium) of the bladders of normal and OAB rats.
HostingRepository	PRIDE
AnnounceDate	2024-10-22
AnnouncementXML	Submission_2024-10-22_04:02:20.089.xml
DigitalObjectIdentifier	https://dx.doi.org/10.6019/PXD007571
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Supported dataset by repository
PrimarySubmitter	Sang-Yeop Lee
SpeciesList	scientific name: Rattus norvegicus (Rat); NCBI TaxID: 10116;
ModificationList	Oxidation; Carbamidomethyl
Instrument	LTQ Orbitrap Velos

Dataset History

Revision	Datetime	Status	ChangeLog Entry
0	2017-08-28 05:48:55	ID requested
1	2018-02-09 09:28:27	announced
⏵ 2	2024-10-22 04:02:26	announced	2024-10-22: Updated project metadata.

Publication List

10.1074/mcp.ra117.000290;
10.6019/PXD007571;
Park EC, Lim JS, Kim SI, Lee SY, Tak YK, Choi CW, Yun S, Park J, Lee M, Chung HK, Kim KS, Na YG, Shin JH, Kim GH, Proteomic Analysis of Urothelium of Rats with Detrusor Overactivity Induced by Bladder Outlet Obstruction. Mol Cell Proteomics, 17(5):948-960(2018) [pubmed]

10.1074/mcp.ra117.000290;

10.6019/PXD007571;

Park EC, Lim JS, Kim SI, Lee SY, Tak YK, Choi CW, Yun S, Park J, Lee M, Chung HK, Kim KS, Na YG, Shin JH, Kim GH, Proteomic Analysis of Urothelium of Rats with Detrusor Overactivity Induced by Bladder Outlet Obstruction. Mol Cell Proteomics, 17(5):948-960(2018) [pubmed]

Keyword List

curator keyword: Biomedical
submitter keyword: OAB, Rat, bladder outlet obstruction, bladder

curator keyword: Biomedical

submitter keyword: OAB, Rat, bladder outlet obstruction, bladder

Contact List

Gun-Hwa Kim
contact affiliation	Drug & Disease Target Team, Division of Bioconvergence Analysis, Korea Basic Science Institute (KBSI), Cheongju 28119, Republic of Korea
contact email	genekgh@kbsi.re.kr
lab head
Sang-Yeop Lee
contact affiliation	Korea Basic Science Institute
contact email	yopi@kbsi.re.kr
dataset submitter

Full Dataset Link List

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PRIDE project URI

Dataset FTP location
NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2018/02/PXD007571

PRIDE project URI

Repository Record List

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