PXD007244

PXD007244 is an original dataset announced via ProteomeXchange.

Dataset Summary

Title	Effect of rRNA methylation defect on protein composition of human ribosomes
Description	Ribosomal RNAs (rRNAs) are main effectors of mRNA decoding, peptide-bond formation and ribosome dynamics during translation. Ribose 2'-O-methylation is the most abundant rRNA chemical modification, and display a complex pattern in rRNA. We globally challenged rRNA 2'-O-Me by inhibiting the rRNA methyl-transferase fibrillarin (FBL) in human cells. Since FBL participates in rRNA processing, we wonder if FBL knockdown could alter the assembly of ribosomes.
HostingRepository	PRIDE
AnnounceDate	2024-10-22
AnnouncementXML	Submission_2024-10-22_04:13:04.685.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Yohann Couté
SpeciesList	scientific name: Homo sapiens (Human); NCBI TaxID: 9606;
ModificationList	monohydroxylated residue; acetylated residue; iodoacetamide derivatized residue
Instrument	LTQ Orbitrap Velos

Dataset History

Revision	Datetime	Status	ChangeLog Entry
0	2017-08-10 05:05:35	ID requested
1	2018-04-09 08:48:29	announced
⏵ 2	2024-10-22 04:13:05	announced	2024-10-22: Updated project metadata.

Publication List

Erales J, Marchand V, Panthu B, Gillot S, Belin S, Ghayad SE, Garcia M, Lafor, ê, ts F, Marcel V, Baudin-Baillieu A, Bertin P, Cout, é Y, Adrait A, Meyer M, Therizols G, Yusupov M, Namy O, Ohlmann T, Motorin Y, Catez F, Diaz JJ, Evidence for rRNA 2'-O-methylation plasticity: Control of intrinsic translational capabilities of human ribosomes. Proc Natl Acad Sci U S A, 114(49):12934-12939(2017) [pubmed]
10.1073/pnas.1707674114;

Erales J, Marchand V, Panthu B, Gillot S, Belin S, Ghayad SE, Garcia M, Lafor, ê, ts F, Marcel V, Baudin-Baillieu A, Bertin P, Cout, é Y, Adrait A, Meyer M, Therizols G, Yusupov M, Namy O, Ohlmann T, Motorin Y, Catez F, Diaz JJ, Evidence for rRNA 2'-O-methylation plasticity: Control of intrinsic translational capabilities of human ribosomes. Proc Natl Acad Sci U S A, 114(49):12934-12939(2017) [pubmed]

10.1073/pnas.1707674114;

Keyword List

curator keyword: Biological
submitter keyword: ribosomes, fibrillarin, nanoLC-MS/MS

curator keyword: Biological

submitter keyword: ribosomes, fibrillarin, nanoLC-MS/MS

Contact List

Brun Virginie
contact affiliation	EDyP
contact email	virginie.brun@cea.fr
lab head
Yohann Couté
contact affiliation	EDyP
contact email	yohann.coute@cea.fr
dataset submitter

Full Dataset Link List

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2018/04/PXD007244
PRIDE project URI

Dataset FTP location
NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2018/04/PXD007244

PRIDE project URI

Repository Record List

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