PXD007234

PXD007234 is an original dataset announced via ProteomeXchange.

Title	Menstrual fluid factors facilitate tissue repair: Identification and functional action in endometrial and skin repair
Description	Repair after damage is essential for tissue homeostasis. Post-menstrual repair of the uterine endometrium is a unique cyclical manifestation of rapid, scar-free, tissue repair taking ~3-5 days. Skin repair post-wounding is slower (~2 weeks) and, in the case of chronic wounds, takes months/years to restore integrity. Herein, the unique ‘rapid-repair’ endometrial environment is translated to the ‘slower-repair’ skin environment. Menstrual fluid (MF), the milieu of post-menstrual endometrial repair, facilitates healing of endometrial and keratinocyte ‘wounds’ in vitro, promoting cellular adhesion and migration, stimulates keratinocyte migration in an ex vivo human skin-reconstruct model and promotes re-epithelialization in an in vivo porcine wound model. Proteomic analysis of MF identified a large number of proteins; several proteins were selected for further investigation, with the endometrium demonstrated as the source of these factors. Functionally, they promote repair of endometrial and keratinocyte wounds by promoting migration, differing significantly from currently available wound-repair treatments, which mainly promote proliferation. Development of these and other menstrual fluid factors into a ‘migration-inducing’ treatment paradigm will provide novel therapies for tissue repair.
HostingRepository	PRIDE
AnnounceDate	2018-07-30
AnnouncementXML	Submission_2018-07-30_02:19:27.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Giuseppe Infusini
SpeciesList	scientific name: Homo sapiens (Human); NCBI TaxID: 9606;
ModificationList	monohydroxylated residue; acetylated residue; iodoacetamide derivatized residue
Instrument	Q Exactive

Revision	Datetime	Status	ChangeLog Entry
0	2017-08-09 06:04:47	ID requested
⏵ 1	2018-07-30 02:19:28	announced

Evans J, Infusini G, McGovern J, Cuttle L, Webb A, Nebl T, Milla L, Kimble R, Kempf M, Andrews CJ, Leavesley D, Salamonsen LA, Menstrual fluid factors facilitate tissue repair: identification and functional action in endometrial and skin repair. FASEB J, 33(1):584-605(2019) [pubmed]

curator keyword: Biological

submitter keyword: Human, woulnd healing factors

Andrew Ian Webb
contact affiliation	Walter and Eliza Hall Institute of medical research
contact email	webb@wehi.edu.au
lab head
Giuseppe Infusini
contact affiliation	WEHI
contact email	infusini@wehi.edu.au
dataset submitter

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PRIDE project URI

• PRIDE
  1. PXD007234
     1. Label: PRIDE project
     2. Name: Menstrual fluid factors facilitate tissue repair: Identification and functional action in endometrial and skin repair