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PXD007234

PXD007234 is an original dataset announced via ProteomeXchange.

Dataset Summary
TitleMenstrual fluid factors facilitate tissue repair: Identification and functional action in endometrial and skin repair
DescriptionRepair after damage is essential for tissue homeostasis. Post-menstrual repair of the uterine endometrium is a unique cyclical manifestation of rapid, scar-free, tissue repair taking ~3-5 days. Skin repair post-wounding is slower (~2 weeks) and, in the case of chronic wounds, takes months/years to restore integrity. Herein, the unique ‘rapid-repair’ endometrial environment is translated to the ‘slower-repair’ skin environment. Menstrual fluid (MF), the milieu of post-menstrual endometrial repair, facilitates healing of endometrial and keratinocyte ‘wounds’ in vitro, promoting cellular adhesion and migration, stimulates keratinocyte migration in an ex vivo human skin-reconstruct model and promotes re-epithelialization in an in vivo porcine wound model. Proteomic analysis of MF identified a large number of proteins; several proteins were selected for further investigation, with the endometrium demonstrated as the source of these factors. Functionally, they promote repair of endometrial and keratinocyte wounds by promoting migration, differing significantly from currently available wound-repair treatments, which mainly promote proliferation. Development of these and other menstrual fluid factors into a ‘migration-inducing’ treatment paradigm will provide novel therapies for tissue repair.
HostingRepositoryPRIDE
AnnounceDate2018-07-30
AnnouncementXMLSubmission_2018-07-30_02:19:27.xml
DigitalObjectIdentifier
ReviewLevelPeer-reviewed dataset
DatasetOriginOriginal dataset
RepositorySupportUnsupported dataset by repository
PrimarySubmitterGiuseppe Infusini
SpeciesList scientific name: Homo sapiens (Human); NCBI TaxID: 9606;
ModificationListmonohydroxylated residue; acetylated residue; iodoacetamide derivatized residue
InstrumentQ Exactive
Dataset History
RevisionDatetimeStatusChangeLog Entry
02017-08-09 06:04:47ID requested
12018-07-30 02:19:28announced
Publication List
Evans J, Infusini G, McGovern J, Cuttle L, Webb A, Nebl T, Milla L, Kimble R, Kempf M, Andrews CJ, Leavesley D, Salamonsen LA, Menstrual fluid factors facilitate tissue repair: identification and functional action in endometrial and skin repair. FASEB J, 33(1):584-605(2019) [pubmed]
Keyword List
curator keyword: Biological
submitter keyword: Human, woulnd healing factors
Contact List
Andrew Ian Webb
contact affiliationWalter and Eliza Hall Institute of medical research
contact emailwebb@wehi.edu.au
lab head
Giuseppe Infusini
contact affiliationWEHI
contact emailinfusini@wehi.edu.au
dataset submitter
Full Dataset Link List
Dataset FTP location
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PRIDE project URI
Repository Record List
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