PXD007234 is an
original dataset announced via ProteomeXchange.
Dataset Summary
Title | Menstrual fluid factors facilitate tissue repair: Identification and functional action in endometrial and skin repair |
Description | Repair after damage is essential for tissue homeostasis. Post-menstrual repair of the uterine endometrium is a unique cyclical manifestation of rapid, scar-free, tissue repair taking ~3-5 days. Skin repair post-wounding is slower (~2 weeks) and, in the case of chronic wounds, takes months/years to restore integrity. Herein, the unique ‘rapid-repair’ endometrial environment is translated to the ‘slower-repair’ skin environment. Menstrual fluid (MF), the milieu of post-menstrual endometrial repair, facilitates healing of endometrial and keratinocyte ‘wounds’ in vitro, promoting cellular adhesion and migration, stimulates keratinocyte migration in an ex vivo human skin-reconstruct model and promotes re-epithelialization in an in vivo porcine wound model. Proteomic analysis of MF identified a large number of proteins; several proteins were selected for further investigation, with the endometrium demonstrated as the source of these factors. Functionally, they promote repair of endometrial and keratinocyte wounds by promoting migration, differing significantly from currently available wound-repair treatments, which mainly promote proliferation. Development of these and other menstrual fluid factors into a ‘migration-inducing’ treatment paradigm will provide novel therapies for tissue repair. |
HostingRepository | PRIDE |
AnnounceDate | 2018-07-30 |
AnnouncementXML | Submission_2018-07-30_02:19:27.xml |
DigitalObjectIdentifier | |
ReviewLevel | Peer-reviewed dataset |
DatasetOrigin | Original dataset |
RepositorySupport | Unsupported dataset by repository |
PrimarySubmitter | Giuseppe Infusini |
SpeciesList | scientific name: Homo sapiens (Human); NCBI TaxID: 9606; |
ModificationList | monohydroxylated residue; acetylated residue; iodoacetamide derivatized residue |
Instrument | Q Exactive |
Dataset History
Revision | Datetime | Status | ChangeLog Entry |
0 | 2017-08-09 06:04:47 | ID requested | |
⏵ 1 | 2018-07-30 02:19:28 | announced | |
Publication List
Evans J, Infusini G, McGovern J, Cuttle L, Webb A, Nebl T, Milla L, Kimble R, Kempf M, Andrews CJ, Leavesley D, Salamonsen LA, Menstrual fluid factors facilitate tissue repair: identification and functional action in endometrial and skin repair. FASEB J, 33(1):584-605(2019) [pubmed] |
Keyword List
curator keyword: Biological |
submitter keyword: Human, woulnd healing factors |
Contact List
Andrew Ian Webb |
contact affiliation | Walter and Eliza Hall Institute of medical research |
contact email | webb@wehi.edu.au |
lab head | |
Giuseppe Infusini |
contact affiliation | WEHI |
contact email | infusini@wehi.edu.au |
dataset submitter | |
Full Dataset Link List
Dataset FTP location
NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2018/07/PXD007234 |
PRIDE project URI |
Repository Record List
[ + ]
[ - ]
- PRIDE
- PXD007234
- Label: PRIDE project
- Name: Menstrual fluid factors facilitate tissue repair: Identification and functional action in endometrial and skin repair