PXD007229

PXD007229 is an original dataset announced via ProteomeXchange.

Title	Rat colon LC-MSMS - Intake of Fish Oil Specifically Modulates Colonic Muc2 Expression in Middle-Aged Rats by Suppressing the Glycosylation Process
Description	Dietary fats have been shown to affect gut microbiota composition and aging gene transcription of middle-aged rats at a normal dose, but little is known about such an effect on gut barrier. In colon, the main component of mucus layer is Muc2, produced by the goblet cells. This study investigated the changes in Muc2 expression, goblet cells proliferation, TLRs and inflammatory cytokines in the colon of middle-aged rats. Proteome technology was applied to explore the possible molecular mechanisms. The results indicated that intake of fish oil at a normal dose downregulated colonic Muc2 expression, and this negative effect of fish oil probably involved the suppression of mucin glycosylation process.
HostingRepository	PRIDE
AnnounceDate	2024-10-22
AnnouncementXML	Submission_2024-10-22_04:12:12.857.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Yafang Ma
SpeciesList	scientific name: Rattus norvegicus (Rat); NCBI TaxID: 10116;
ModificationList	TMT6plex-126 reporter+balance reagent acylated residue
Instrument	LTQ Orbitrap

Revision	Datetime	Status	ChangeLog Entry
0	2017-08-09 05:55:45	ID requested
1	2018-01-02 03:42:23	announced
⏵ 2	2024-10-22 04:12:13	announced	2024-10-22: Updated project metadata.

Ma Y, Zhou G, Li Y, Zhu Y, Yu X, Zhao F, Li H, Xu X, Li C, Intake of Fish Oil Specifically Modulates Colonic Muc2 Expression in Middle-Aged Rats by Suppressing the Glycosylation Process. Mol Nutr Food Res, 62(4):(2018) [pubmed]

10.1002/mnfr.201700661;

curator keyword: Biological

submitter keyword: LC-MSMS,Rat, colon

Chunbao Li
contact affiliation	Nanjing Agricultural University
contact email	chunbao.li@njau.edu.cn
lab head
Yafang Ma
contact affiliation	student
contact email	2015108035@njau.edu.cn
dataset submitter

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2018/01/PXD007229

PRIDE project URI

• PRIDE
  1. PXD007229
     1. Label: PRIDE project
     2. Name: Rat colon LC-MSMS - Intake of Fish Oil Specifically Modulates Colonic Muc2 Expression in Middle-Aged Rats by Suppressing the Glycosylation Process