PXD007193

PXD007193 is an original dataset announced via ProteomeXchange.

Title	Plasma Mouse LC-MSMS - Bortezomib administered prior to temozolomide depletes MGMT, chemosensitizes glioblastoma with unmethylated MGMT promoter and prolongs animal survival
Description	Patients diagnosed with glioblastoma (GBM) with sustained synthesis of the DNA repair enzyme, O6-methyl guanine DNA methytransferase (MGMT), are rendered resistant to Temozolomide (TMZ) chemotherapy. Here, we hypothesized that pretreatment with the proteasome inhibitor Bortezomib (BTZ, Velcade) might sensitize these GBM to TMZ by depleting MGMT.
HostingRepository	PRIDE
AnnounceDate	2024-10-22
AnnouncementXML	Submission_2024-10-22_04:39:53.928.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Frode Selheim
SpeciesList	scientific name: Mus musculus (Mouse); NCBI TaxID: 10090;
ModificationList	monohydroxylated residue; iodoacetamide derivatized residue
Instrument	LTQ Orbitrap Velos

Revision	Datetime	Status	ChangeLog Entry
0	2017-08-04 05:33:32	ID requested
1	2019-08-20 07:03:53	announced
⏵ 2	2024-10-22 04:40:02	announced	2024-10-22: Updated project metadata.

Rahman MA, Gras Navarro A, Brekke J, Engelsen A, Bindesb, ø, ll C, Sarowar S, Bahador M, Bifulco E, Goplen D, Waha A, Lie SA, Gjertsen BT, Selheim F, Enger P Ø, Simonsen A, Chekenya M, Bortezomib administered prior to temozolomide depletes MGMT, chemosensitizes glioblastoma with unmethylated MGMT promoter and prolongs animal survival. Br J Cancer, 121(7):545-555(2019) [pubmed]

10.1038/s41416-019-0551-1;

curator keyword: Biological

submitter keyword: Glioblastoma, Plasma, Mouse,Autophagy

Martha Chekenya
contact affiliation	Department of Biomedicine, University of Bergen, Norway
contact email	martha.enger@uib.no
lab head
Frode Selheim
contact affiliation	University
contact email	frode.selheim@biomed.uib.no
dataset submitter

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2019/08/PXD007193

PRIDE project URI

• PRIDE
  1. PXD007193
     1. Label: PRIDE project
     2. Name: Plasma Mouse LC-MSMS - Bortezomib administered prior to temozolomide depletes MGMT, chemosensitizes glioblastoma with unmethylated MGMT promoter and prolongs animal survival