PXD007185

PXD007185 is an original dataset announced via ProteomeXchange.

Title	Neuropilin-2 (NRP2) is the receptor for human cytomegalovirus (HCMV) pentameric complex and is responsible for HCMV infection
Description	Chemical cross-linking coupled to mass spectrometry was used to study the complex between the HMCV pentameric complex (gH/gL/UL128/UL130/UL131A) and its receptor, neuropilin-2 (NRP2). Cross-linking was performed using either disuccinimidyl suberate (DSS) or a combination of pimelic acid dihydrazide (PDH) and the coupling reagent, DMTMM.
HostingRepository	PRIDE
AnnounceDate	2018-07-26
AnnouncementXML	Submission_2018-08-08_00:33:46.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Alexander Leitner
SpeciesList	scientific name: Homo sapiens (Human); NCBI TaxID: 9606;
ModificationList	iodoacetamide derivatized residue
Instrument	LTQ Orbitrap Elite

Revision	Datetime	Status	ChangeLog Entry
0	2017-08-03 07:19:21	ID requested
1	2018-07-26 08:11:20	announced
⏵ 2	2018-08-08 00:33:47	announced	Updated publication reference for PubMed record(s): 30057110.

Martinez-Martin N, Marcandalli J, Huang CS, Arthur CP, Perotti M, Foglierini M, Ho H, Dosey AM, Shriver S, Payandeh J, Leitner A, Lanzavecchia A, Perez L, Ciferri C, An Unbiased Screen for Human Cytomegalovirus Identifies Neuropilin-2 as a Central Viral Receptor. Cell, 174(5):1158-1171.e19(2018) [pubmed]

curator keyword: Biological, Biomedical

submitter keyword: Chemical cross-linking

DSS

structural proteomics

human cytomegalovirus

viral entry

receptor proteins

Claudio Ciferri
contact affiliation	Department of Structural Biology, Genentech Inc. South San Francisco, CA 94080, USA
contact email	ciferric@gene.com
lab head
Alexander Leitner
contact affiliation	ETH Zurich, Institute of Molecular Systems Biology
contact email	leitner@imsb.biol.ethz.ch
dataset submitter

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2018/07/PXD007185

PRIDE project URI

• PRIDE
  1. PXD007185
     1. Label: PRIDE project
     2. Name: Neuropilin-2 (NRP2) is the receptor for human cytomegalovirus (HCMV) pentameric complex and is responsible for HCMV infection