PXD007150

PXD007150 is an original dataset announced via ProteomeXchange.

Title	Hippocampal proteomic profiling following peripheral delivery of klotho fragment
Description	We found that a klotho protein fragment (KL-F), administered peripherally, induced cognitive enhancement and neural resilience. Here we report a proteomic analysis of whole hippocampal homogenates from mice treated with vehicle or KL-F (10 µg/kg, i.p.) four hours prior to exploration in the small Y-maze. The proteomic results showed glutamate receptor signaling as the top enriched canonical pathway by Ingenuity Pathway Analysis.
HostingRepository	PRIDE
AnnounceDate	2017-08-15
AnnouncementXML	Submission_2017-08-15_00:30:40.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Jakob Vowinckel
SpeciesList	scientific name: Mus musculus (Mouse); NCBI TaxID: 10090;
ModificationList	monohydroxylated residue; acetylated residue; iodoacetamide derivatized residue
Instrument	Q Exactive

Revision	Datetime	Status	ChangeLog Entry
0	2017-07-28 07:35:17	ID requested
1	2017-08-09 01:49:43	announced
⏵ 2	2017-08-15 00:30:40	announced	Updated project metadata.

Dataset with its publication pending

curator keyword: Biological, Biomedical

submitter keyword: Klotho, hippocampus, SWATH, DIA, Biognosys

Dena B. Dubal, MD, PhD
contact affiliation	Department of Neurology and Weill Institute for Neurosciences, University of California, San Francisco
contact email	Dena.Dubal@ucsf.edu
lab head
Jakob Vowinckel
contact affiliation	Biognosys AG
contact email	jakob.vowinckel@biognosys.com
dataset submitter

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2017/08/PXD007150

PRIDE project URI

• PRIDE
  1. PXD007150
     1. Label: PRIDE project
     2. Name: Hippocampal proteomic profiling following peripheral delivery of klotho fragment