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PXD007137

DataSet Summary

  • HostingRepository: PRIDE
  • AnnounceDate: 2018-01-12
  • AnnouncementXML: Submission_2018-01-12_05:56:59.xml
  • DigitalObjectIdentifier: http://dx.doi.org/10.6019/PXD007137
  • ReviewLevel: Peer-reviewed dataset
  • DatasetOrigin: Original data
  • RepositorySupport: Supported dataset by repository
  • PrimarySubmitter: Brent Kuenzi
  • Title: Ceritinib Functional Proteomics
  • Description: To elucidate the mechanism of action (MoA) of ceritinib’s antiproliferative activity in these cells, we applied a systems approach combining both chemical and phosphoproteomics to gain a global view of ceritinib’s target profile and network-wide phosphorylation changes following ceritinib treatment.
  • SpeciesList: scientific name: Homo sapiens (Human); NCBI TaxID: 9606;
  • ModificationList: Phospho; Label:13C(6)15N(4); Oxidation; Label:13C(6); Carbamidomethyl
  • Instrument: Q Exactive; LTQ Orbitrap

Dataset History

VersionDatetimeStatusChangeLog Entry
02017-07-26 08:33:50ID requested
12018-01-12 05:57:01announced

Publication List

  1. Kuenzi BM, Remsing Rix LL, Stewart PA, Fang B, Kinose F, Bryant AT, Boyle TA, Koomen JM, Haura EB, Rix U, Polypharmacology-based ceritinib repurposing using integrated functional proteomics. Nat Chem Biol, 13(12):1222-1231(2017) [pubmed]

Keyword List

  1. curator keyword: Biomedical
  2. submitter keyword: Chemical proteomics, phosphoproteomics

Contact List

    Uwe Rix
    • contact affiliation: Moffitt Cancer Center
    • contact email: uwe.rix@moffitt.org
    • lab head:
    Brent Kuenzi
    • contact affiliation: Moffitt Cancer Center
    • contact email: brent.kuenzi@moffitt.org
    • dataset submitter:

Full Dataset Link List

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  2. PRIDE project URI
Repository Record List
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