PXD007125 is an
original dataset announced via ProteomeXchange.
Dataset Summary
Title | Proteomic analysis of meningioma of different grades identifies potential therapeutic targets and biomarkers |
Description | Meningiomas are common brain tumours arising from meningeal tissue. Despite the majority of them displaying benign features, they can cause mild to severe morbidity. The current main therapeutic approach is complete tumour resection commonly with adjunct radiation therapy. However, tumour location can hamper complete resection and chemotherapies are ineffective. In this study we aim to elucidate dysregulated pathways in meningioma pathogenesis and identify novel molecular targets by deciphering the proteome and phosphoproteome of different grades of meningiomas. Tumour lysates were collected from grade I, II and III frozenmeningioma specimens and three normal healthy human meninges. |
HostingRepository | PRIDE |
AnnounceDate | 2019-01-02 |
AnnouncementXML | Submission_2019-01-02_06:11:57.xml |
DigitalObjectIdentifier | |
ReviewLevel | Peer-reviewed dataset |
DatasetOrigin | Original dataset |
RepositorySupport | Unsupported dataset by repository |
PrimarySubmitter | Jemma Dunn |
SpeciesList | scientific name: Homo sapiens (Human); NCBI TaxID: 9606; |
ModificationList | phosphorylated residue |
Instrument | LTQ Orbitrap Velos |
Dataset History
Revision | Datetime | Status | ChangeLog Entry |
0 | 2017-07-25 05:55:55 | ID requested | |
⏵ 1 | 2019-01-02 06:11:58 | announced | |
Publication List
Dunn J, Ferluga S, Sharma V, Futschik M, Hilton DA, Adams CL, Lasonder E, Hanemann CO, Proteomic analysis discovers the differential expression of novel proteins and phosphoproteins in meningioma including NEK9, HK2 and SET and deregulation of RNA metabolism. EBioMedicine, 40():77-91(2019) [pubmed] |
Keyword List
curator keyword: Biomedical |
submitter keyword: Meningioma, proteomics |
Contact List
Prof. O. Hanemann |
contact affiliation | Plymouth University Peninsula Schools of Medicine and Dentistry |
contact email | oliver.hanemann@plymouth.ac.uk |
lab head | |
Jemma Dunn |
contact affiliation | Plymouth University Peninsula School of Medicine and Dentistry |
contact email | jemma.dunn@plymouth.ac.uk |
dataset submitter | |
Full Dataset Link List
Dataset FTP location
NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2019/01/PXD007125 |
PRIDE project URI |
Repository Record List
[ + ]
[ - ]
- PRIDE
- PXD007125
- Label: PRIDE project
- Name: Proteomic analysis of meningioma of different grades identifies potential therapeutic targets and biomarkers