PXD007116

PXD007116 is an original dataset announced via ProteomeXchange.

Title	Mitotic post-translational modifications of histones promote chromatin compaction in vitro
Description	As histones undergo major changes in their post-translational modifications during mitotic entry, we speculated that the spectrum of cell cycle-specific histone modifications might contribute to chromosome compaction during mitosis. To test this hypothesis, we isolated core histones from interphase and mitotic cells and reconstituted chromatin with them. We used mass spectrometry to show that key post-translational modifications remained intact during our isolation procedure.
HostingRepository	PRIDE
AnnounceDate	2018-10-24
AnnouncementXML	Submission_2018-10-24_11:30:07.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Juan Jose Bonfiglio
SpeciesList	scientific name: Gallus gallus (Chicken); NCBI TaxID: 9031;
ModificationList	monomethylated residue; ubiquitinylated lysine; phosphorylated residue; N6: N6; N6-propanoyl-L-lysine; acetylated residue; dimethylated residue
Instrument	Q Exactive

Revision	Datetime	Status	ChangeLog Entry
0	2017-07-25 01:14:40	ID requested
⏵ 1	2018-10-24 11:30:08	announced

Zhiteneva A, Bonfiglio JJ, Makarov A, Colby T, Vagnarelli P, Schirmer EC, Matic I, Earnshaw WC, . Open Biol, 7(9):(2017) [pubmed]

curator keyword: Biological

submitter keyword: Chromatin condensation, Mitotic histones, Histones, PTMs

William Earnshaw
contact affiliation	University of Edinburgh, Wellcome Trust Centre for Cell Biology
contact email	Bill.Earnshaw@ed.ac.uk
lab head
Juan Jose Bonfiglio
contact affiliation	CECAD Research Group, Max Planck Institute for Biology of Ageing, Cologne, Germany
contact email	jbonfiglio@age.mpg.de
dataset submitter

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2018/10/PXD007116

PRIDE project URI

• PRIDE
  1. PXD007116
     1. Label: PRIDE project
     2. Name: Mitotic post-translational modifications of histones promote chromatin compaction in vitro