PXD007099

PXD007099 is an original dataset announced via ProteomeXchange.

Dataset Summary

Title	ZBTB2 as a novel reader for unmethylated DNA
Description	In this study, we investigated the dynamics during differentiation of the in vivo binding sites of ZBTB2, a putative reader for unmethylated DNA. We performed DNA pull-downs followed by mass spectrometry, using a genomic sequence containing either unmethylated or methylated CpGs, to study the influence of DNA methylation on ZBTB2 binding. Additionally, we performed interaction proteomics to identify ZBTB2 interaction partners. We found that ZBTB2 recruits a zinc finger module of three proteins to unmethylated DNA.
HostingRepository	PRIDE
AnnounceDate	2024-10-22
AnnouncementXML	Submission_2024-10-22_04:39:40.968.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Ino Karemaker
SpeciesList	scientific name: Mus musculus (Mouse); NCBI TaxID: 10090;
ModificationList	No PTMs are included in the dataset
Instrument	Orbitrap Fusion; Q Exactive

Dataset History

Revision	Datetime	Status	ChangeLog Entry
0	2017-07-21 06:28:28	ID requested
1	2018-01-31 00:21:00	announced
2	2018-02-27 08:05:59	announced	Updated publication reference for PubMed record(s): 29437775.
⏵ 3	2024-10-22 04:39:45	announced	2024-10-22: Updated project metadata.

Publication List

10.15252/embr.201744993;
Karemaker ID, Vermeulen M, ZBTB2 reads unmethylated CpG island promoters and regulates embryonic stem cell differentiation. EMBO Rep, 19(4):(2018) [pubmed]

10.15252/embr.201744993;

Karemaker ID, Vermeulen M, ZBTB2 reads unmethylated CpG island promoters and regulates embryonic stem cell differentiation. EMBO Rep, 19(4):(2018) [pubmed]

Keyword List

curator keyword: Biological
submitter keyword: Mouse, ESC, NPC,ZBTB2

curator keyword: Biological

submitter keyword: Mouse, ESC, NPC,ZBTB2

Contact List

Michiel Vermeulen
contact affiliation	Department of Molecular Biology, Faculty of Science, Radboud Institute for Molecular Life Sciences, Radboud University Nijmegen, Nijmegen, the Netherlands
contact email	Michiel.Vermeulen@science.ru.nl
lab head
Ino Karemaker
contact affiliation	University of Zurich
contact email	ino.karemaker@uzh.ch
dataset submitter

Full Dataset Link List

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2018/01/PXD007099
PRIDE project URI

Dataset FTP location
NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2018/01/PXD007099

PRIDE project URI

Repository Record List

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