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PXD007086

PXD007086 is an original dataset announced via ProteomeXchange.

Dataset Summary
TitleAn immunoproteomic approach to characterize the CAR interactome and signalosome
DescriptionAdoptive transfer of chimeric antigen receptor (CAR)-T cells is expected to become the first line of treatment for multiple malignancies, following the enormous success of anti-CD19 therapies. However, their mechanism of action is not fully understood, and clear guidelines for the design of safe and efficient receptors are missing. We hereby describe a systematic analysis of the CAR “signalosome” in human primary T cells. Two CAR designs were compared: a second-generation (PSCA2) and a third-generation (PSCA3) anti-PSCA CAR. Phosphorylation events triggered by CAR-mediated recognition of target cells were quantified by mass spectrometry.
HostingRepositoryPRIDE
AnnounceDate2024-10-22
AnnouncementXMLSubmission_2024-10-22_04:39:42.312.xml
DigitalObjectIdentifierhttps://dx.doi.org/10.6019/PXD007086
ReviewLevelPeer-reviewed dataset
DatasetOriginOriginal dataset
RepositorySupportSupported dataset by repository
PrimarySubmitterJohn Koomen
SpeciesList scientific name: Homo sapiens (Human); NCBI TaxID: 9606;
ModificationListNo PTMs are included in the dataset
InstrumentQ Exactive
Dataset History
RevisionDatetimeStatusChangeLog Entry
02017-07-20 02:56:29ID requested
12019-11-06 23:42:52announced
22024-10-22 04:39:47announced2024-10-22: Updated project metadata.
Publication List
10.1126/scisignal.aap9777;
10.6019/PXD007086;
Ramello MC, Benza, ï, d I, Kuenzi BM, Lienlaf-Moreno M, Kandell WM, Santiago DN, Pab, ó, n-Salda, ñ, a M, Darville L, Fang B, Rix U, Yoder S, Berglund A, Koomen JM, Haura EB, Abate-Daga D, An immunoproteomic approach to characterize the CAR interactome and signalosome. Sci Signal, 12(568):(2019) [pubmed]
Keyword List
curator keyword: Biomedical
submitter keyword: Phosphoproteomics,Chimeric Antigen Receptors, Tonic Signaling
Contact List
Daniel Abate-Daga
contact affiliationMoffitt Cancer Center
contact emaildaniel.abatedaga@moffitt.org
lab head
John Koomen
contact affiliationMoffitt Cancer Center
contact emailjohn.koomen@moffitt.org
dataset submitter
Full Dataset Link List
Dataset FTP location
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PRIDE project URI
Repository Record List
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