PXD007056

PXD007056 is an original dataset announced via ProteomeXchange.

Title	Discovery proteomics studies for the identification of a protein panel associated with the response to pemetrexed in platinum drug resistant cancer
Description	Pemetrexed is a drug largely used in lung cancer, mesothelioma and proposed in some cases of ovarian cancers, a particularly severe cancer type. In this latest tumor type, therapy relies on debulking surgery and platinum-based chemotherapy. Despite the initial high response rates to platinum drugs, most patients relapse and die from the disease. Considering the high levels of thymidylate synthase, dhydrofolate reductase and other folate related proteins in platinum drug resistant patients, pemetrexed was proposed as a second line drugs due to its known mechanism of action that engage the mentioned proteins. However a successful outcome could only be expected on the basis of patients’ stratifications. In the present study, a discovery proteomics approach was applied to tissue samples collected beforepemetrexed treatment from platinum resistant patients who relapsed after the first-line carboplatin-based chemotherapy but responded differently to the pemetrexed treatment.
HostingRepository	PRIDE
AnnounceDate	2024-10-22
AnnouncementXML	Submission_2024-10-22_04:40:32.277.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Stefania Ferrari
SpeciesList	scientific name: Homo sapiens (Human); NCBI TaxID: 9606;
ModificationList	iodoacetamide derivatized residue
Instrument	impact HD

Revision	Datetime	Status	ChangeLog Entry
0	2017-07-17 01:32:01	ID requested
1	2018-06-06 08:27:56	announced
⏵ 2	2024-10-22 04:40:40	announced	2024-10-22: Updated project metadata.

Severi L, Losi L, Fonda S, Taddia L, Gozzi G, Marverti G, Magni F, Chinello C, Stella M, Sheouli J, Braicu EI, Genovese F, Lauriola A, Marraccini C, Gualandi A, D'Arca D, Ferrari S, Costi MP, Proteomic and Bioinformatic Studies for the Characterization of Response to Pemetrexed in Platinum Drug Resistant Ovarian Cancer. Front Pharmacol, 9():454(2018) [pubmed]

10.3389/fphar.2018.00454;

curator keyword: Biomedical

submitter keyword: platinum drug resistance, LC MS/MS,ovarian cancer, discovery proteomics

Stefania Ferrari
contact affiliation	Department of Life Sciences, University of Mdoena and Reggio Emilia
contact email	stefania.ferrari@unimore.it
lab head
Stefania Ferrari
contact affiliation	University of Modena and Reggio Emilia
contact email	stefania.ferrari@unimore.it
dataset submitter

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2018/06/PXD007056

PRIDE project URI

• PRIDE
  1. PXD007056
     1. Label: PRIDE project
     2. Name: Discovery proteomics studies for the identification of a protein panel associated with the response to pemetrexed in platinum drug resistant cancer