PXD007048

PXD007048 is an original dataset announced via ProteomeXchange.

Title	Cell-specific proteome analyses of human bone marrow upon aging.
Description	Diminishing potential to replace damaged tissues is a hallmark for aging of somatic stem cells, but the mechanisms leading to aging remain elusive. We performed a proteome-wide analysis of human hematopoietic stem and progenitor cells (CD34+) along with five other cell types that constitute the bone marrow niche, namely, lymphocytes and precursors; monocytes/macrophages and precursors; granulocytic precursors and erythroid precursors, as well as mesenchymal stem/stromal cells. In total, we analyzed 270 samples from 59 human subjects. The data represents a valuable resource for further in-depth mechanistic analyses, and for validation of knowledge gained from animal models.
HostingRepository	PRIDE
AnnounceDate	2018-07-31
AnnouncementXML	Submission_2019-02-12_08:32:46.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Marco L. Hennrich
SpeciesList	scientific name: Homo sapiens (Human); NCBI TaxID: 9606;
ModificationList	No PTMs are included in the dataset
Instrument	LTQ Orbitrap Velos

Revision	Datetime	Status	ChangeLog Entry
0	2017-07-14 04:11:15	ID requested
1	2018-07-31 00:48:16	announced
⏵ 2	2019-02-12 08:32:48	announced	Updated publication reference for PubMed record(s): 30275468.

Hennrich ML, Romanov N, Horn P, Jaeger S, Eckstein V, Steeples V, Ye F, Ding X, Poisa-Beiro L, Lai MC, Lang B, Boultwood J, Luft T, Zaugg JB, Pellagatti A, Bork P, Aloy P, Gavin AC, Ho AD, Cell-specific proteome analyses of human bone marrow reveal molecular features of age-dependent functional decline. Nat Commun, 9(1):4004(2018) [pubmed]

curator keyword: Biological

submitter keyword: aging, hematopoietic stem cells, mesenchymal stem/stromal cells, human, TMT, label-free quantification

Anne-Claude Gavin
contact affiliation	EMBL Heidelberg
contact email	gavin@embl.de
lab head
Marco L. Hennrich
contact affiliation	EMBL Heidelberg
contact email	marco.hennrich@embl.de
dataset submitter

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2018/07/PXD007048

PRIDE project URI

• PRIDE
  1. PXD007048
     1. Label: PRIDE project
     2. Name: Cell-specific proteome analyses of human bone marrow upon aging.