PXD007046
PXD007046 is an original dataset announced via ProteomeXchange.
Dataset Summary
Title | Mutant JAK3 phosphoproteomic profiling predicts synergism between JAK3 inhibitors and MEK/PI3K/BCL2 inhibitors for the treatment of T-cell acute lymphoblastic leukemia |
Description | Mutations in the interleukin-7 receptor (IL7R) or the JAK3 kinase occur frequently in T-cell acute lymphoblastic leukemia (T-ALL) and both are able to drive cellular transformation and the development of T-ALL in mouse models. However, the signal transduction pathways downstream of JAK3 mutations remain poorly characterized. Here, we describe the phosphoproteome downstream of the JAK3(L857Q)/(M511I) activating mutations in transformed Ba/F3 lymphocyte cells and human JAK3 mutated T-ALL samples . Novel peptides shown to be downstream of mutant JAK3 regulating RNA metabolism as well as epigenetic and apoptotic processes were validated using targeted PRM proteomics. |
HostingRepository | MassIVE |
AnnounceDate | 2017-08-21 |
AnnouncementXML | Submission_2017-08-21_19:51:47.xml |
DigitalObjectIdentifier | |
ReviewLevel | Non peer-reviewed dataset |
DatasetOrigin | Original dataset |
RepositorySupport | Supported dataset by repository |
PrimarySubmitter | Matt Dun |
SpeciesList | scientific name: Mus musculus; common name: house mouse; NCBI TaxID: 10090; scientific name: Homo sapiens; common name: human; NCBI TaxID: 9606; |
ModificationList | Phospho; Acetyl; Oxidation |
Instrument | Q Exactive |
Dataset History
Revision | Datetime | Status | ChangeLog Entry |
---|---|---|---|
0 | 2017-07-14 01:58:55 | ID requested | |
⏵ 1 | 2017-08-21 19:51:48 | announced |
Publication List
no publication |
Keyword List
submitter keyword: T-ALL, JAK3, L857Q, M511I, TMT10plex, DDA, PRM, Phosphoproteomic Profiling |
Contact List
Dr. Matt Dun | |
---|---|
contact affiliation | University of Newcastle |
contact email | Matt.Dun@newcastle.edu.au |
lab head | |
Matt Dun | |
contact affiliation | HMRI Cancer Research Program UoN |
contact email | Matt.Dun@newcastle.edu.au |
dataset submitter |
Full Dataset Link List
MassIVE dataset URI |
Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://massive.ucsd.edu/MSV000081327 |