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PXD007046

PXD007046 is an original dataset announced via ProteomeXchange.

Dataset Summary
TitleMutant JAK3 phosphoproteomic profiling predicts synergism between JAK3 inhibitors and MEK/PI3K/BCL2 inhibitors for the treatment of T-cell acute lymphoblastic leukemia
DescriptionMutations in the interleukin-7 receptor (IL7R) or the JAK3 kinase occur frequently in T-cell acute lymphoblastic leukemia (T-ALL) and both are able to drive cellular transformation and the development of T-ALL in mouse models. However, the signal transduction pathways downstream of JAK3 mutations remain poorly characterized. Here, we describe the phosphoproteome downstream of the JAK3(L857Q)/(M511I) activating mutations in transformed Ba/F3 lymphocyte cells and human JAK3 mutated T-ALL samples . Novel peptides shown to be downstream of mutant JAK3 regulating RNA metabolism as well as epigenetic and apoptotic processes were validated using targeted PRM proteomics.
HostingRepositoryMassIVE
AnnounceDate2017-08-21
AnnouncementXMLSubmission_2017-08-21_19:51:47.xml
DigitalObjectIdentifier
ReviewLevelNon peer-reviewed dataset
DatasetOriginOriginal dataset
RepositorySupportSupported dataset by repository
PrimarySubmitterMatt Dun
SpeciesList scientific name: Mus musculus; common name: house mouse; NCBI TaxID: 10090; scientific name: Homo sapiens; common name: human; NCBI TaxID: 9606;
ModificationListPhospho; Acetyl; Oxidation
InstrumentQ Exactive
Dataset History
RevisionDatetimeStatusChangeLog Entry
02017-07-14 01:58:55ID requested
12017-08-21 19:51:48announced
Publication List
no publication
Keyword List
submitter keyword: T-ALL, JAK3, L857Q, M511I, TMT10plex, DDA, PRM, Phosphoproteomic Profiling
Contact List
Dr. Matt Dun
contact affiliationUniversity of Newcastle
contact emailMatt.Dun@newcastle.edu.au
lab head
Matt Dun
contact affiliationHMRI Cancer Research Program UoN
contact emailMatt.Dun@newcastle.edu.au
dataset submitter
Full Dataset Link List
MassIVE dataset URI
Dataset FTP location
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