PXD007046

PXD007046 is an original dataset announced via ProteomeXchange.

Dataset Summary

Title	Mutant JAK3 phosphoproteomic profiling predicts synergism between JAK3 inhibitors and MEK/PI3K/BCL2 inhibitors for the treatment of T-cell acute lymphoblastic leukemia
Description	Mutations in the interleukin-7 receptor (IL7R) or the JAK3 kinase occur frequently in T-cell acute lymphoblastic leukemia (T-ALL) and both are able to drive cellular transformation and the development of T-ALL in mouse models. However, the signal transduction pathways downstream of JAK3 mutations remain poorly characterized. Here, we describe the phosphoproteome downstream of the JAK3(L857Q)/(M511I) activating mutations in transformed Ba/F3 lymphocyte cells and human JAK3 mutated T-ALL samples . Novel peptides shown to be downstream of mutant JAK3 regulating RNA metabolism as well as epigenetic and apoptotic processes were validated using targeted PRM proteomics.
HostingRepository	MassIVE
AnnounceDate	2017-08-21
AnnouncementXML	Submission_2017-08-21_19:51:47.xml
DigitalObjectIdentifier
ReviewLevel	Non peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Supported dataset by repository
PrimarySubmitter	Matt Dun
SpeciesList	scientific name: Mus musculus; common name: house mouse; NCBI TaxID: 10090; scientific name: Homo sapiens; common name: human; NCBI TaxID: 9606;
ModificationList	Phospho; Acetyl; Oxidation
Instrument	Q Exactive

Dataset History

Revision	Datetime	Status	ChangeLog Entry
0	2017-07-14 01:58:55	ID requested
⏵ 1	2017-08-21 19:51:48	announced

Publication List

no publication

no publication

Keyword List

submitter keyword: T-ALL, JAK3, L857Q, M511I, TMT10plex, DDA, PRM, Phosphoproteomic Profiling

submitter keyword: T-ALL, JAK3, L857Q, M511I, TMT10plex, DDA, PRM, Phosphoproteomic Profiling

Contact List

Dr. Matt Dun
contact affiliation	University of Newcastle
contact email	Matt.Dun@newcastle.edu.au
lab head
Matt Dun
contact affiliation	HMRI Cancer Research Program UoN
contact email	Matt.Dun@newcastle.edu.au
dataset submitter

Full Dataset Link List

MassIVE dataset URI
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MassIVE dataset URI

Dataset FTP location
NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://massive.ucsd.edu/MSV000081327