PXD007044

PXD007044 is an original dataset announced via ProteomeXchange.

Title	Proteomic analysis of meningioma of different grades identifies potential therapeutic targets and biomarkers
Description	Meningiomas are common brain tumours arising from meningeal tissue. Despite the majority of them displaying benign features, they can cause mild to severe morbidity. The current main therapeutic approach is complete tumour resection commonly with adjunct radiation therapy. However, tumour location can hamper complete resection and chemotherapies are ineffective. In this study we aim to elucidate dysregulated pathways in meningioma pathogenesis and identify novel molecular targets by deciphering the proteome and phosphoproteome of different grades of meningiomas. Tumour lysates were collected from grade I, II and III frozemeningioma specimens and three normal healthy human meninges.
HostingRepository	PRIDE
AnnounceDate	2019-01-07
AnnouncementXML	Submission_2019-01-07_06:21:19.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Jemma Dunn
SpeciesList	scientific name: Homo sapiens (Human); NCBI TaxID: 9606;
ModificationList	deaminated residue; monohydroxylated residue; acetylated residue
Instrument	LTQ Orbitrap Velos

Revision	Datetime	Status	ChangeLog Entry
0	2017-07-14 01:00:23	ID requested
⏵ 1	2019-01-07 06:21:21	announced

Dunn J, Ferluga S, Sharma V, Futschik M, Hilton DA, Adams CL, Lasonder E, Hanemann CO, Proteomic analysis discovers the differential expression of novel proteins and phosphoproteins in meningioma including NEK9, HK2 and SET and deregulation of RNA metabolism. EBioMedicine, 40():77-91(2019) [pubmed]

curator keyword: Biomedical

submitter keyword: Meningioma, LC-MS/MS

Clemens Oliver Hanemann
contact affiliation	Director Institute of Translational and Stratified Medicine, Plymouth University Peninsula Schools of Medicine and Dentistry, UK
contact email	oliver.hanemann@plymouth.ac.uk
lab head
Jemma Dunn
contact affiliation	Plymouth University Peninsula School of Medicine and Dentistry
contact email	jemma.dunn@plymouth.ac.uk
dataset submitter

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2019/01/PXD007044

PRIDE project URI

• PRIDE
  1. PXD007044
     1. Label: PRIDE project
     2. Name: Proteomic analysis of meningioma of different grades identifies potential therapeutic targets and biomarkers