PXD006988

PXD006988 is an original dataset announced via ProteomeXchange.

Title	The Arabidopsis kinase YODA regulates non-canonical immune responses conferring broad-spectrum disease resistance
Description	Mitogen-activated protein kinases (MAPK) cascades play essential roles in plants and animals by transducing developmental cues and environmental signals into cellular responses. Among the latter are microbe-associated molecular patterns perceived by plant pattern recognition receptors (PRRs), which trigger immunity. We found that YODA (YDA), a MAPK kinase kinase regulating several Arabidopsis developmental processes, like stomatal and embryo patterning, also modulates immune responses. Resistance to pathogens is compromised in a yda11 hypomorphic allele whereas plants expressing the constitutively active YDA (CA-YDA) protein show broad-spectrum disease resistance to necrotrophic and biotrophic fungi, bacteria and oomycetes. We found that YDA functions downstream ERECTA (ER) Receptor-Like Kinase regulating both immunity and stomatal patterning. ER/YDA-mediated immune responses act in parallel to canonical disease resistance pathways regulated by defensive phytohormones and PRRs, like FLS2 and CERK1, which are required for bacterial and fungal resistance, respectively. CA-YDA plants constitutively express defense-associated genes and exhibit altered cell wall integrity, which contribute to their broad-spectrum disease resistance. CA-YDA plants also show a strong reprogramming of their phosphoproteome, which contains protein targets that do not significantly overlap with described plant MAPKs substrates. Our data suggest that plants might have evolutionarily co-opted the stomata development pathway regulated by ER/YDA to generate a novel immune surveillance system that is distinct from the canonical immune pathways mediated by previously described PRRs and plant defensive hormones.
HostingRepository	PRIDE
AnnounceDate	2024-10-22
AnnouncementXML	Submission_2024-10-22_04:39:38.496.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Ines Lassowskat
SpeciesList	scientific name: Arabidopsis thaliana (Mouse-ear cress); NCBI TaxID: 3702;
ModificationList	phosphorylated residue
Instrument	LTQ Orbitrap Velos

Revision	Datetime	Status	ChangeLog Entry
0	2017-07-11 23:49:29	ID requested
1	2018-02-21 01:43:02	announced
⏵ 2	2024-10-22 04:39:46	announced	2024-10-22: Updated project metadata.

10.1111/nph.15007;

Sope, ñ, a-Torres S, Jord, á L, S, á, nchez-Rodr, í, guez C, Miedes E, Escudero V, Swami S, L, ó, pez G, Pi, ś, lewska-Bednarek M, Lassowskat I, Lee J, Gu Y, Haigis S, Alexander D, Pattathil S, Mu, ñ, oz-Barrios A, Bednarek P, Somerville S, Schulze-Lefert P, Hahn MG, Scheel D, Molina A, YODA MAP3K kinase regulates plant immune responses conferring broad-spectrum disease resistance. New Phytol, 218(2):661-680(2018) [pubmed]

curator keyword: Biological

submitter keyword: Arabidopsis thaliana, resistance, phosphorylation, leaf

Dierk Scheel
contact affiliation	Leibniz-Institut für Pflanzenbiochemie Weinberg 3 06120 Halle (Saale)
contact email	Dierk.Scheel@ipb-halle.de
lab head
Ines Lassowskat
contact affiliation	WWU Münster
contact email	ilasso@uni-muenster.de
dataset submitter

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2018/02/PXD006988

PRIDE project URI

• PRIDE
  1. PXD006988
     1. Label: PRIDE project
     2. Name: The Arabidopsis kinase YODA regulates non-canonical immune responses conferring broad-spectrum disease resistance