PXD006938

PXD006938 is an original dataset announced via ProteomeXchange.

Dataset Summary

Title	Human Mitochondria NFS1-ISCU-FXN XL-MS
Description	Frataxin (FXN) is involved in mitochondrial iron-sulfur (Fe-S) cluster biogenesis and serves to accelerate Fe-S cluster formation. FXN deficiency is associated with Friedreich ataxia, a neurodegenerative disease. Using chemical cross-linking (XL) accompanied with LC-MS/MS, we studied the the interaction between the core complexes Acp-ISD11-NFS1 (AIN) and AIN-ISCU (AINU) with FXN.
HostingRepository	PRIDE
AnnounceDate	2024-10-22
AnnouncementXML	Submission_2024-10-22_04:39:28.635.xml
DigitalObjectIdentifier	https://dx.doi.org/10.6019/PXD006938
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Supported dataset by repository
PrimarySubmitter	Kai Cai
SpeciesList	scientific name: Homo sapiens (Human); NCBI TaxID: 9606;
ModificationList	Deamidated; Oxidation; Carbamidomethyl
Instrument	LTQ Orbitrap

Dataset History

Revision	Datetime	Status	ChangeLog Entry
0	2017-07-11 07:25:17	ID requested
1	2018-07-11 07:16:12	announced
⏵ 2	2024-10-22 04:39:36	announced	2024-10-22: Updated project metadata.

Publication List

10.6019/PXD006938;
Cai K, Frederick RO, Dashti H, Markley JL, Architectural Features of Human Mitochondrial Cysteine Desulfurase Complexes from Crosslinking Mass Spectrometry and Small-Angle X-Ray Scattering. Structure, 26(8):1127-1136.e4(2018) [pubmed]
10.1016/j.str.2018.05.017;

10.6019/PXD006938;

Cai K, Frederick RO, Dashti H, Markley JL, Architectural Features of Human Mitochondrial Cysteine Desulfurase Complexes from Crosslinking Mass Spectrometry and Small-Angle X-Ray Scattering. Structure, 26(8):1127-1136.e4(2018) [pubmed]

10.1016/j.str.2018.05.017;

Keyword List

curator keyword: Biological
submitter keyword: Mitochondria, Iron-sulfur cluster, XL-MS

curator keyword: Biological

submitter keyword: Mitochondria, Iron-sulfur cluster, XL-MS

Contact List

John L. Markley
contact affiliation	University of Wisconsin-Madison
contact email	markley@biochem.wisc.edu
lab head
Kai Cai
contact affiliation	University of Wisconsin-Madison
contact email	kcai@wisc.edu
dataset submitter

Full Dataset Link List

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2018/07/PXD006938
PRIDE project URI

Dataset FTP location
NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2018/07/PXD006938

PRIDE project URI

Repository Record List

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