PXD006931

PXD006931 is an original dataset announced via ProteomeXchange.

Dataset Summary

Title	Bioactive natural product peptide discovery in fungal secretoms using PepSAVI-MS
Description	Fungal secondary metabolites represent a rich and largely untapped source for bioactive molecules, including peptides with substantial structural diversity and pharmacological potential. As methods proceed to take a deep dive into fungal genomes, complimentary methods to identify bioactive components are required to keep pace with the expanding fungal repertoire. We developed PepSAVI-MS to expedite the search for natural product bioactive peptides and herein demonstrate proof-of-principle applicability of the pipeline for the discovery of bioactive peptides from fungal secretomes via identification of the antifungal killer toxin KP4 from Ustilago maydis P4. This work opens the door to investigating microbial secretomes with a new lens, and could have broad applications across human health, agriculture, and food safety.
HostingRepository	PRIDE
AnnounceDate	2024-10-22
AnnouncementXML	Submission_2024-10-22_04:42:47.662.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Christine Kirkpatrick
SpeciesList	scientific name: Ustilago maydis virus P4; NCBI TaxID: 11009;
ModificationList	No PTMs are included in the dataset
Instrument	TripleTOF 5600

Dataset History

Revision	Datetime	Status	ChangeLog Entry
0	2017-07-11 02:54:34	ID requested
1	2018-02-19 02:51:25	announced
⏵ 2	2024-10-22 04:42:55	announced	2024-10-22: Updated project metadata.

Publication List

10.1007/s13361-017-1880-z;
Kirkpatrick CL, Parsley NC, Bartges TE, Cooke ME, Evans WS, Heil LR, Smith TJ, Hicks LM, Fungal Secretome Analysis via PepSAVI-MS: Identification of the Bioactive Peptide KP4 from Ustilago maydis. J Am Soc Mass Spectrom, 29(5):859-865(2018) [pubmed]

10.1007/s13361-017-1880-z;

Kirkpatrick CL, Parsley NC, Bartges TE, Cooke ME, Evans WS, Heil LR, Smith TJ, Hicks LM, Fungal Secretome Analysis via PepSAVI-MS: Identification of the Bioactive Peptide KP4 from Ustilago maydis. J Am Soc Mass Spectrom, 29(5):859-865(2018) [pubmed]

Keyword List

curator keyword: Biological
submitter keyword: peptidomics, mass spectrometry, fungal secretome analysis,Bioactive peptides

curator keyword: Biological

submitter keyword: peptidomics, mass spectrometry, fungal secretome analysis,Bioactive peptides

Contact List

Leslie M. Hicks
contact affiliation	UNC Chapel Hill
contact email	lmhicks@unc.edu
lab head
Christine Kirkpatrick
contact affiliation	UNC Chapel Hill
contact email	ckirkpat@live.unc.edu
dataset submitter

Full Dataset Link List

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2018/02/PXD006931
PRIDE project URI

Dataset FTP location
NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2018/02/PXD006931

PRIDE project URI

Repository Record List

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