PXD006911

PXD006911 is an original dataset announced via ProteomeXchange.

Title	myocardial tissue from atrial fibrillation patients
Description	Electrical and structural remodeling processes are contributors to the self-perpetuating nature of atrial fibrillation (AF). However, their correlation has not been clarified. In this study, human atrial tissues from the patients with rheumatic mitral valve disease in either sinus rhythm or persistent AF were analyzed using a combined transcriptomic and proteomic approach. An up-regulation in chloride intracellular channel (CLIC) 1, 4, 5 and a rise in type IV collagen were revealed. Combined with the results from immunohistochemistry and electron microscope analysis, the distribution of type IV collagen and effects of fibrosis on myocyte membrane indicated the possible interaction between CLIC and type IV collagen, confirmed by protein structure prediction and co-immunoprecipitation. These results indicate that CLICs play an important role in the development of atrial fibrillation and that CLICs and structural type IV collagen may interact on each other to promote the development of AF in rheumatic mitral valve disease.
HostingRepository	PRIDE
AnnounceDate	2018-11-22
AnnouncementXML	Submission_2018-11-22_01:57:50.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Jiang Yiyao
SpeciesList	scientific name: Homo sapiens (Human); NCBI TaxID: 9606;
ModificationList	iodoacetamide derivatized residue
Instrument	Q Exactive

Revision	Datetime	Status	ChangeLog Entry
0	2017-07-10 02:40:51	ID requested
⏵ 1	2018-11-22 01:57:52	announced

Jiang YY, Hou HT, Yang Q, Liu XC, He GW, Chloride Channels are Involved in the Development of Atrial Fibrillation - A Transcriptomic and proteomic Study. Sci Rep, 7(1):10215(2017) [pubmed]

curator keyword: Biomedical

submitter keyword: human, heart, iTRAQ,

Jiang Yiyao
contact affiliation	Department of Cardiovascular Surgery & Center for Basic Medical Research, TEDA International Cardiovascular Hospital, The Chinese Academy of Medical Sciences & Nankai University, Tianjin, China
contact email	jiangyiyao0309@sina.com
lab head
Jiang Yiyao
contact affiliation	TEDA International Cardiovascular Hospital
contact email	jiangyiyao0309@sina.com
dataset submitter

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2018/11/PXD006911

PRIDE project URI

• PRIDE
  1. PXD006911
     1. Label: PRIDE project
     2. Name: myocardial tissue from atrial fibrillation patients