PXD006907

PXD006907 is an original dataset announced via ProteomeXchange.

Title	S-nitrosylation in Shank3 mutated mice
Description	We tested the hypothesis that a mutated gene associated with human ASD would generate downstream effects in critical proteins that lead to modification of synaptic functions.
HostingRepository	PRIDE
AnnounceDate	2018-10-02
AnnouncementXML	Submission_2018-10-02_07:18:16.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Haitham Amal
SpeciesList	scientific name: Mus musculus (Mouse); NCBI TaxID: 10090;
ModificationList	iodoacetamide derivatized residue
Instrument	6520 Quadrupole Time-of-Flight LC/MS

Revision	Datetime	Status	ChangeLog Entry
0	2017-07-10 01:25:24	ID requested
⏵ 1	2018-10-02 07:18:17	announced

Amal H, Barak B, Bhat V, Gong G, Joughin BA, Wang X, Wishnok JS, Feng G, Tannenbaum SR, Shank3 mutation in a mouse model of autism leads to changes in the S-nitroso-proteome and affects key proteins involved in vesicle release and synaptic function. Mol Psychiatry, 25(8):1835-1848(2020) [pubmed]

ProteomeXchange project tag: Biology/Disease-Driven Human Proteome Project (B/D-HPP)

curator keyword: Biological

submitter keyword: S-nitrosylation, nitric oxide, autism, ASD, neurotransmission

Prof. Steven R. Tannenbaum
contact affiliation	Departments of Biological Engineering and Chemistry, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.
contact email	srt@mit.edu
lab head
Haitham Amal
contact affiliation	Massachusetts Institute of Technology (MIT)
contact email	hamal@mit.edu
dataset submitter

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2018/10/PXD006907

PRIDE project URI

• PRIDE
  1. PXD006907
     1. Label: PRIDE project
     2. Name: S-nitrosylation in Shank3 mutated mice