PXD006902
PXD006902 is an original dataset announced via ProteomeXchange.
Dataset Summary
| Title | Quantitative chemical proteomic profiling of phosphoprotein phosphatases |
| Description | We have developed a chemical proteomic strategy for the systematic interrogation of endogenous phosphoprotein phosphatases (PPP) and their interacting proteins, including regulatory and scaffolding subunits, and substrates (the 'PPPome'). PPPs are captured using an immobilized non-selective PPP inhibitor, followed by identification and quantification by mass spectrometry. Using this approach, we map the PPPome in human cancer cell lines, mouse tissues, and yeast species, identify cell and tissue type specific PPP expression patterns, and discover new PPP interacting proteins. |
| HostingRepository | MassIVE |
| AnnounceDate | 2018-09-24 |
| AnnouncementXML | Submission_2018-09-24_12:01:58.xml |
| DigitalObjectIdentifier | |
| ReviewLevel | Peer-reviewed dataset |
| DatasetOrigin | Original dataset |
| RepositorySupport | Supported dataset by repository |
| PrimarySubmitter | Mark Adamo |
| SpeciesList | scientific name: Homo sapiens; common name: human; NCBI TaxID: 9606; scientific name: Mus musculus; common name: house mouse; NCBI TaxID: 10090; scientific name: Neurospora crassa; NCBI TaxID: 5141; scientific name: Candida albicans; NCBI TaxID: 5476; scientific name: Saccharomyces cerevisiae; common name: baker's yeast; NCBI TaxID: 4932; scientific name: Schizosaccharomyces pombe; common name: fission yeast; NCBI TaxID: 4896; |
| ModificationList | S-carboxamidomethyl-L-cysteine; L-methionine sulfoxide; TMT6plex |
| Instrument | instrument model: Q Exactive Plus; Orbitrap Fusion |
Dataset History
| Revision | Datetime | Status | ChangeLog Entry |
|---|---|---|---|
| 0 | 2017-07-07 07:50:53 | ID requested | |
| ⏵ 1 | 2018-09-24 12:02:00 | announced |
Publication List
| Lyons SP, Jenkins NP, Nasa I, Choy MS, Adamo ME, Page R, Peti W, Moorhead GB, Kettenbach AN, A Quantitative Chemical Proteomic Strategy for Profiling Phosphoprotein Phosphatases from Yeast to Humans. Mol Cell Proteomics, 17(12):2448-2461(2018) [pubmed] |
Keyword List
| submitter keyword: PPP, phosphoprotein phosphatases, PPPome, quantitative, proteomics, human cancer cell lines, A172, T47D, MCF7, SKBR3, expression, interaction |
Contact List
| Arminja Kettenbach | |
|---|---|
| contact affiliation | The Geisel School of Medicine at Dartmouth |
| contact email | arminja.n.kettenbach@dartmouth.edu |
| lab head | |
| Mark Adamo | |
| contact affiliation | Dartmouth College |
| contact email | mark.e.adamo@dartmouth.edu |
| dataset submitter | |
Full Dataset Link List
| MassIVE dataset URI |
| Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://massive.ucsd.edu/MSV000081226 |
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