PXD006889

PXD006889 is an original dataset announced via ProteomeXchange.

Title	Mass spec analysis of primary human erythroid cultures (healthy or thalassemic and treated or untreated with Decitabine)
Description	Reactivation of gamma-globin is considered a promising approach for the treatment of beta-thalassaemia and sickle cell disease. Therapeutic induction of gamma-globin expression is fraught with lack of suitable therapeutic targets. In order to identify new potential targets we analysed the changes in the proteome of human primary erythroid progenitor cells by treatment with decitabine, a known, yet not clinically safe, gamma-globin inducer. Significant differentially expressed proteins were identified which were involved in various biological pathways and functional categories.
HostingRepository	PRIDE
AnnounceDate	2024-10-22
AnnouncementXML	Submission_2024-10-22_04:39:23.064.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Eleni Katsantoni
SpeciesList	scientific name: Homo sapiens (Human); NCBI TaxID: 9606;
ModificationList	No PTMs are included in the dataset
Instrument	LTQ Orbitrap Elite

Revision	Datetime	Status	ChangeLog Entry
0	2017-07-07 01:15:08	ID requested
1	2020-01-23 03:22:32	announced
⏵ 2	2024-10-22 04:39:27	announced	2024-10-22: Updated project metadata.

10.3390/jcm9010134;

Theodorou A, Phylactides M, Katsantoni E, Vougas K, Garbis SD, Fanis P, Sitarou M, Thein SL, Kleanthous M, -Globin Induction by Decitabine in Human Primary Erythroid Progenitor Cultures. J Clin Med, 9(1):(2020) [pubmed]

curator keyword: Biomedical

submitter keyword: Human, Decitabine, HbF, LC-MS, primary erythroid cultures

Eleni Katsantoni
contact affiliation	Biomedical Research Foundation, Academy of Athens Basic Research Center Soranou tou Ephessiou 4 115.27 Athens Greece Tel: +30 210 6597221 Fax: +30 210 6597545 www.bioacademy.gr
contact email	ekatsantoni@bioacademy.gr
lab head
Eleni Katsantoni
contact affiliation	Biomedical Research Foundation, Academy of Athens
contact email	ekatsantoni@bioacademy.gr
dataset submitter

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2020/01/PXD006889

PRIDE project URI

• PRIDE
  1. PXD006889
     1. Label: PRIDE project
     2. Name: Mass spec analysis of primary human erythroid cultures (healthy or thalassemic and treated or untreated with Decitabine)