PXD006882 is an
original dataset announced via ProteomeXchange.
Dataset Summary
Title | Human (21d bed rest) Muscle LC-MSMS |
Description | Muscle atrophy is one of the main deleterious consequences of physical inactivity. Bed rest represents a unique model of physical inactivity and results in main changes in muscle metabolic function. However, our knowledge on the detrimental effects of bed rest still needs clarification. The aim of this study was to decipher the mechanisms involved in disuse muscle atrophy and the effects of different countermeasures in healthy men. A cross-over trial was designed, with each trial consisting in a 7-day ambulatory control period for baseline data collection, followed by 21 days head-down tilt bed rest with or without resistive vibration exercise only or combined with nutritional (protein) supplement as countermeasures. The changes in the Vastus lateralis muscle proteome collected in the eight volunteers were characterized using mass spectrometry-based label-free quantitative proteomics. |
HostingRepository | PRIDE |
AnnounceDate | 2024-10-22 |
AnnouncementXML | Submission_2024-10-22_05:08:42.644.xml |
DigitalObjectIdentifier | |
ReviewLevel | Peer-reviewed dataset |
DatasetOrigin | Original dataset |
RepositorySupport | Unsupported dataset by repository |
PrimarySubmitter | Fabrice BERTILE |
SpeciesList | scientific name: Homo sapiens (Human); NCBI TaxID: 9606; |
ModificationList | monohydroxylated residue; acetylated residue; iodoacetamide derivatized residue |
Instrument | Q Exactive Plus |
Dataset History
Revision | Datetime | Status | ChangeLog Entry |
0 | 2017-07-06 03:35:50 | ID requested | |
1 | 2020-07-07 06:54:14 | announced | |
⏵ 2 | 2024-10-22 05:08:44 | announced | 2024-10-22: Updated project metadata. |
Publication List
10.1021/acs.jproteome.0c00256; |
Kenny HC, Tascher G, Ziemianin A, Rudwill F, Zahariev A, Chery I, Gauquelin-Koch G, Barielle MP, Heer M, Blanc S, O'Gorman DJ, Bertile F, Effectiveness of Resistive Vibration Exercise and Whey Protein Supplementation Plus Alkaline Salt on the Skeletal Muscle Proteome Following 21 Days of Bed Rest in Healthy Males. J Proteome Res, 19(8):3438-3451(2020) [pubmed] |
Keyword List
curator keyword: Biomedical |
submitter keyword: Human, LC-MSMS, countermeasures, inactivity, muscle, atrophy |
Contact List
Sarah Cianférani |
contact affiliation | Laboratoire de Spectrométrie de Masse BioOrganique, Analytical Science department, IPHC, CNRS, Strasbourg University, UMR7178, Strasbourg, France |
contact email | sarah.cianferani@unistra.fr |
lab head | |
Fabrice BERTILE |
contact affiliation | CNRS |
contact email | fbertile@unistra.fr |
dataset submitter | |
Full Dataset Link List
Dataset FTP location
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PRIDE project URI |
Repository Record List
[ + ]
[ - ]
- PRIDE
- PXD006882
- Label: PRIDE project
- Name: Human (21d bed rest) Muscle LC-MSMS