PXD006863

PXD006863 is an original dataset announced via ProteomeXchange.

Title	TMT-FASP-LC-MS analysis of peritoneal dialysis effluent
Description	Peritoneal dialysis (PD) is a modality of renal replacement therapy in which the high volumes of available PD effluent (PDE) represents a rich source of biomarkers for monitoring disease and therapy. Although this information could help guiding the management of PD patients, little is known about the potential of PDE to define pathomechanism-associated molecular signatures in PD. Here we present the utilization of a high-performance multiplex proteomics approach based on depletion of highly abundant plasma proteins and enrichment of low abundance proteins and quantitation using a combination of label-free and isobaric labeling strategies for PDE samples from PD patients (n=20), who received either standard PD fluid or a novel PD fluid (added alanyl-glutamine (AlaGln)) in an open-label, randomized, two-period, cross-over clinical trial.
HostingRepository	PRIDE
AnnounceDate	2018-01-05
AnnouncementXML	Submission_2018-01-05_00:30:30.xml
DigitalObjectIdentifier	https://dx.doi.org/10.6019/PXD006863
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Supported dataset by repository
PrimarySubmitter	Klaus Kratochwill
SpeciesList	scientific name: Homo sapiens (Human); NCBI TaxID: 9606;
ModificationList	TMT6plex; Oxidation; Carbamidomethyl
Instrument	LTQ Orbitrap Velos

Revision	Datetime	Status	ChangeLog Entry
0	2017-07-03 23:38:17	ID requested
1	2017-12-13 06:34:47	announced
⏵ 2	2018-01-05 00:30:31	announced	Updated project metadata.

Herzog R, Boehm M, Unterwurzacher M, Wagner A, Parapatics K, M, á, jek P, Mueller AC, Lichtenauer A, Bennett KL, Alper SL, Vychytil A, Aufricht C, Kratochwill K, Effects of Alanyl-Glutamine Treatment on the Peritoneal Dialysis Effluent Proteome Reveal Pathomechanism-Associated Molecular Signatures. Mol Cell Proteomics, 17(3):516-532(2018) [pubmed]

curator keyword: Biomedical

submitter keyword: peritoneal dialysis, plasma proteins, biomarkers, TMT, cytoprotection

Klaus Kratochwill
contact affiliation	Department of Pediatrics and Adolescent Medicine, Medical University of Vienna, Austria
contact email	klaus.kratochwill@meduniwien.ac.at
lab head
Klaus Kratochwill
contact affiliation	Medical University of Vienna
contact email	klaus.kratochwill@meduniwien.ac.at
dataset submitter

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2012/12/PXD006863

PRIDE project URI

• PRIDE
  1. PXD006863
     1. Label: PRIDE project
     2. Name: TMT-FASP-LC-MS analysis of peritoneal dialysis effluent