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PXD006828

PXD006828 is an original dataset announced via ProteomeXchange.

Dataset Summary
TitlePRMT5: a Novel Regulator of Hepatitis B Virus Replication and an Arginine Methylase of HBV Core
DescriptionIn the study, we identified protein arginine methyltransferase 5 (PRMT5) as a novel restriction factor of HBV replication. We have also demonstrated that PRMT5 can interact with the HBV core and methylate its arginine residues within arginine-rich domain. We identified two types of HBc post-translational modifications: arginine methylation and ubiquitination. While monomethylated HBc retains cytoplasmic localization, symmetric dimethylation is linked to serine phosphorylation and nuclear transport. Thus arginine methylation and ubiquitination are novel types of HBc post-translational modifications which add another level of complexity to the understanding of HBc function and regulation of HBV replication
HostingRepositoryPRIDE
AnnounceDate2024-10-22
AnnouncementXMLSubmission_2024-10-22_04:39:50.259.xml
DigitalObjectIdentifier
ReviewLevelPeer-reviewed dataset
DatasetOriginOriginal dataset
RepositorySupportUnsupported dataset by repository
PrimarySubmitterMartin Hubalek
SpeciesList scientific name: Hepatitis B virus; NCBI TaxID: NCBITaxon:10407; scientific name: Homo sapiens (Human); NCBI TaxID: 9606;
ModificationListubiquitinylated lysine; dimethylated L-arginine; phosphorylated residue; iodoacetamide derivatized residue
InstrumentTripleTOF 5600
Dataset History
RevisionDatetimeStatusChangeLog Entry
02017-06-29 01:56:50ID requested
12017-11-01 03:46:39announced
22024-10-22 04:39:51announced2024-10-22: Updated project metadata.
Publication List
10.1371/journal.pone.0186982;
Lubyova B, Hodek J, Zabransky A, Prouzova H, Hubalek M, Hirsch I, Weber J, PRMT5: A novel regulator of Hepatitis B virus replication and an arginine methylase of HBV core. PLoS One, 12(10):e0186982(2017) [pubmed]
Keyword List
curator keyword: Biological, Biomedical
submitter keyword: Ubiquitination,Hepatitis B Virus, Arginine methylation, phosphorylation, HBV Core protein
Contact List
Martin Hubalek
contact affiliationInstitute of Organic Chemistry and Biochemistry, Czech Academy of Sciences
contact emailhubalek@uochb.cas.cz
lab head
Martin Hubalek
contact affiliationInstitute of Organic Chemistry and Biochemistry, Czech Academy of Science
contact emailhubalek@uochb.cas.cz
dataset submitter
Full Dataset Link List
Dataset FTP location
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PRIDE project URI
Repository Record List
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