PXD006828 is an
original dataset announced via ProteomeXchange.
Dataset Summary
Title | PRMT5: a Novel Regulator of Hepatitis B Virus Replication and an Arginine Methylase of HBV Core |
Description | In the study, we identified protein arginine methyltransferase 5 (PRMT5) as a novel restriction factor of HBV replication. We have also demonstrated that PRMT5 can interact with the HBV core and methylate its arginine residues within arginine-rich domain. We identified two types of HBc post-translational modifications: arginine methylation and ubiquitination. While monomethylated HBc retains cytoplasmic localization, symmetric dimethylation is linked to serine phosphorylation and nuclear transport. Thus arginine methylation and ubiquitination are novel types of HBc post-translational modifications which add another level of complexity to the understanding of HBc function and regulation of HBV replication |
HostingRepository | PRIDE |
AnnounceDate | 2024-10-22 |
AnnouncementXML | Submission_2024-10-22_04:39:50.259.xml |
DigitalObjectIdentifier | |
ReviewLevel | Peer-reviewed dataset |
DatasetOrigin | Original dataset |
RepositorySupport | Unsupported dataset by repository |
PrimarySubmitter | Martin Hubalek |
SpeciesList | scientific name: Hepatitis B virus; NCBI TaxID: NCBITaxon:10407; scientific name: Homo sapiens (Human); NCBI TaxID: 9606; |
ModificationList | ubiquitinylated lysine; dimethylated L-arginine; phosphorylated residue; iodoacetamide derivatized residue |
Instrument | TripleTOF 5600 |
Dataset History
Revision | Datetime | Status | ChangeLog Entry |
0 | 2017-06-29 01:56:50 | ID requested | |
1 | 2017-11-01 03:46:39 | announced | |
⏵ 2 | 2024-10-22 04:39:51 | announced | 2024-10-22: Updated project metadata. |
Publication List
10.1371/journal.pone.0186982; |
Lubyova B, Hodek J, Zabransky A, Prouzova H, Hubalek M, Hirsch I, Weber J, PRMT5: A novel regulator of Hepatitis B virus replication and an arginine methylase of HBV core. PLoS One, 12(10):e0186982(2017) [pubmed] |
Keyword List
curator keyword: Biological, Biomedical |
submitter keyword: Ubiquitination,Hepatitis B Virus, Arginine methylation, phosphorylation, HBV Core protein |
Contact List
Martin Hubalek |
contact affiliation | Institute of Organic Chemistry and Biochemistry, Czech Academy of Sciences |
contact email | hubalek@uochb.cas.cz |
lab head | |
Martin Hubalek |
contact affiliation | Institute of Organic Chemistry and Biochemistry, Czech Academy of Science |
contact email | hubalek@uochb.cas.cz |
dataset submitter | |
Full Dataset Link List
Dataset FTP location
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PRIDE project URI |
Repository Record List
[ + ]
[ - ]
- PRIDE
- PXD006828
- Label: PRIDE project
- Name: PRMT5: a Novel Regulator of Hepatitis B Virus Replication and an Arginine Methylase of HBV Core